MedPath

Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer

Phase 3
Terminated
Conditions
Stage III Rectal Cancer
Adenocarcinoma of the Rectum
Stage II Rectal Cancer
Interventions
Registration Number
NCT00303628
Lead Sponsor
ECOG-ACRIN Cancer Research Group
Brief Summary

Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving more than one drug (combination chemotherapy) together with bevacizumab after surgery may kill any tumor cells that remain after surgery. It is not yet known whether oxaliplatin, leucovorin, and fluorouracil is more effective with or without bevacizumab in treating rectal cancer. This randomized phase III trial is studying combination chemotherapy to see how well it works with or without bevacizumab in treating patients who have had surgery for stage II or stage III rectal cancer.

Detailed Description

PRIMARY OBJECTIVES:

I. Compare the overall survival of patients who have undergone prior surgery and neoadjuvant chemoradiotherapy for clinical stage II or III rectal cancer treated with adjuvant oxaliplatin, leucovorin calcium, fluorouracil with vs without bevacizumab.

SECONDARY OBJECTIVES:

I. Evaluate tolerance of treatment, patterns of failure, and disease-free survival in patients treated with these regimens

EXPLORATORY OBJECTIVES:

I. Assess long-term rectal function using the Patient Bowel Function/Uniscale questionnaire and the Functional Assessment of Cancer (FACT)-Diarrhea subscale in patients treated with these regimens.

II. Validate the FACT-Diarrhea subscale. III. Assess long-term symptoms of oxaliplatin-related neurotoxicity using the FACT/Gynecologic Oncology Group (GOG)-Neurotoxicity subscale in patients treated with these regimens.

IV. Correlate TS, DPD and TP expression (key targets for fluorouracil); retention of chromosome 18q alleles and microsatellite instability (MSI) with TGFβ1RII mutation (markers for fluorouracil efficacy); ERCC1, ERCC2, and XPF expression (participants in repair of adducts from oxaliplatin); and p53 gene mutation and possibly other molecular markers pertinent to vascular endothelial growth factor in tumor tissue specimens with treatment efficacy in these patients.

V. Correlate tumor molecular prognostic markers (chromosome 18q allelic loss and MSI) with survival in patients treated with this regimen.

OUTLINE:

This is a randomized study. Patients are stratified according to Eastern Cooperative Oncology Group (ECOG) performance status (0 vs 1), clinical staging (high risk \[T3, N+, M0 or T4, any N, M0\] vs low risk \[T1-2, N+, M0 or T3, N0, M0\]), prior pre-operative oxaliplatin (yes vs no), and prior radiotherapy dose (40-50 Gy vs \> 50-55.8 Gy). Patients are randomized to 1 of 2 treatment arms in a 1:1 ratio.

ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks for up to 12 courses\* in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive bevacizumab\*\* IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I\*.

\[Note: \*Patients who received prior neoadjuvant oxaliplatin including patients on protocol NSABP-R-04 receive up to 9 courses of treatment followed by leucovorin calcium IV and fluorouracil IV with (arm II) or without (arm I) bevacizumab for up to 3 courses.\]

\[Note: \*\*Patients no longer receive bevacizumab as of 4/29/2009 when accrual was terminated due to slow accrual for the study)\]

Patients complete 10-15 minute questionnaires about bowel function at randomization, end of treatment, 12 months post-treatment and then annually to 5 years post-treatment.

After completion of study treatment, patients are followed periodically for approximately 10 years.

PROJECTED ACCRUAL: 2100 patients

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
355
Inclusion Criteria
  • Histologically confirmed adenocarcinoma of the rectum meeting 1 of the following clinical (e.g., before neoadjuvant therapy) or pathologic staging criteria:

    • T3, N+, M0
    • T3, N0, M0
    • T4, N0, M0
    • Any T, N1-2, M0
  • T4, N0-2, M0 disease must meet 1 of the following criteria:

    • Clinically fixed tumor on rectal examination with tumor adherent to the pelvic sidewall or sacrum
    • Hydronephrosis on Computed Tomography (CT) scan or Intravenous Pyelogram (IVP)
    • Ureteric or bladder invasion as documented by cystoscopy and cytology or biopsy
    • Invasion into prostate
    • Vaginal or uterine involvement
  • Must have undergone complete tumor resection >= 28 days ago and able to begin treatment by day 56

  • Must have undergone concurrent neoadjuvant chemoradiotherapy*

    • NOTE: *Neoadjuvant chemoradiotherapy received on protocol NSABP-R-04 allowed provided it met these criteria
  • Must have undergone prior radiotherapy at 40-55.8 Gy** AND received 1 of the following chemotherapy regimens:

    • Continuous infusion of fluorouracil with or without oxaliplatin; fluorouracil and leucovorin calcium
    • Capecitabine with or without oxaliplatin; capecitabine with or without oxaliplatin OR a continuous infusion of fluorouracil with or without oxaliplatin received on protocol NSABP-R-04
    • NOTE: **Intensity-modulated radiotherapy allowed
  • ECOG performance status 0-1

  • Platelet count >= 100,000/mm^3

  • Absolute granulocyte count >= 1,500/mm^3

  • Bilirubin normal (unless chronic grade 1 bilirubin elevation due to Gilbert's disease or similar syndrome due to slow conjugation of bilirubin)

  • Alkaline phosphatase (AP) < 2.5 times upper limit of normal (ULN) and aspartate aminotransferase (AST) < 1.5 times ULN

  • Hepatitis B and C negative (for patients with AP > normal) unless previously vaccinated

  • Serum creatinine =< 1.5 times ULN

  • Urine protein:creatinine (UPC) ratio < 1.0 OR urine protein < 1 g on 24-hour urine collection

  • International Normalized Ratio (INR) =< 1.5

  • INR > 1.5 allowed provided patient is on full-dose anticoagulants AND meets all of the following criteria:

    • In-range INR (i.e., between 2 and 3) on a stable dose of warfarin or low molecular weight heparin
    • No active bleeding or pathological condition that is associated with a high risk of bleeding
  • Negative pregnancy test

  • Fertile patients must use effective contraception during and for at least 3 months after study treatment

  • No other previous or concurrent malignancy except nonmelanoma skin cancer, breast cancer in situ, carcinoma in situ of the cervix, or previously treated nonpelvic cancer that has been disease-free for > 5 years

  • Patients with a history of breast cancer (without evidence of disease) who remain on hormonal therapy for > 5 years are eligible

  • Patients with a history of hypertension must have blood pressure < 150/90 mm Hg AND be on a stable regimen of antihypertensive therapy

  • No other prior chemotherapy or pelvic radiotherapy except as neoadjuvant treatment for current diagnosis of rectal cancer

  • Concurrent participation on protocol NSABP-R-04 allowed

Exclusion Criteria
  • Pregnant or nursing

  • Evidence of metastatic disease on the surgical/intraoperative examination

  • Evidence of metastatic disease confirmed by CT scan, Magnetic resonance imaging (MRI), or ultrasound of the liver or chest CT scan or chest x-ray within the past 6 months

  • Evidence of tumor outside of the pelvis, including liver metastases, peritoneal seeding, or metastatic inguinal lymphadenopathy

  • Concurrent major surgery

  • Active bleeding not related to the primary rectal tumor within the past 6 months

  • Active inflammatory bowel disease or other serious medical illness which might limit the ability of the patient to receive protocol therapy

  • Active gastroduodenal ulcer determined by endoscopy

  • Serious or nonhealing wound, skin ulcer, or bone fracture

  • Clinically significant peripheral sensory or motor neuropathy >= grade 2

  • Nonmalignant systemic disease (e.g., cardiovascular, renal, or hepatic) that would preclude study treatment including, but not limited to, any of the following:

    • New York Heart Association class III or IV congestive heart failure
    • Concurrent symptomatic arrhythmia
  • Transient ischemic attack or cerebrovascular accident

  • Arterial thromboembolic event, unstable angina, or myocardial infarction within the past 12 months

  • Significant peripheral vascular disease

  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude study requirements

  • Significant traumatic injury within the past 28 days

  • Known allergy to platinum compounds

  • Prior invasive procedure, including either of the following:

    • Major surgical procedure or open biopsy within the past 28 days
    • Core biopsy or other minor procedure, except placement of a vascular access device, within the past 7 days

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Arm IIleucovorin calciumPatients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Arm Ileucovorin calciumPatients receive oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks for up to 12 courses.
Arm IfluorouracilPatients receive oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks for up to 12 courses.
Arm IoxaliplatinPatients receive oxaliplatin IV over 2 hours, leucovorin calcium IV over 2 hours, and fluorouracil IV on day 1 followed by fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks for up to 12 courses.
Arm IIoxaliplatinPatients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Arm IIfluorouracilPatients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Arm IIbevacizumabPatients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive oxaliplatin, leucovorin calcium, and fluorouracil as in arm I.
Primary Outcome Measures
NameTimeMethod
5-year Overall Survival RateFollow-up assessments performed every 3 months for patients < 2 years from randomization, every 6 months for patients 2-5 years from randomization, and every 12 months for patients 5-10 years from randomization

Overall survival (OS) was defined as time from randomization to date of death from any cause. Patients who were still alive were censored at last date of known alive. Kaplan-Meier method was used to estimate the 5-year OS rate.

Secondary Outcome Measures
NameTimeMethod
5-year Disease-free Survival RateFollow-up assessments performed every 3 months for patients < 2 years from randomization, every 6 months for patients 2-5 years from randomization, and every 12 months for patients 5-10 years from randomization

Disease-free survival (DFS) was defined as time from randomization to recurrence, second invasive primary cancer or death, whichever occurred first. Patients who were still alive and had no DFS events were censored at the last disease assessment date known to be free of DFS events. Kaplan-Meier method was used to estimate 5-year DFS rate.

Patterns of FailureFollow-up assessments performed every 3 months for patients < 2 years from randomization, every 6 months for patients 2-5 years from randomization, and every 12 months for patients 5-10 years from randomization

Failure included recurrence, second primary cancer and death without recurrence.

Proportion of Patients Who Completed 12 Cycles of Treatmentassessed at the end of treatment

In the study, treatment was repeated every 2 weeks for a total of 12 cycles on both arms. The total number of cycles of treatment patient received until going off treatment due to any reason was recorded. It was a measure of the tolerance of the therapy.

Trial Locations

Locations (612)

Fox Chase Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Case Western Reserve University

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Foundation

🇺🇸

Cleveland, Ohio, United States

Kaiser Permanente Medical Center - Santa Clara

🇺🇸

Santa Clara, California, United States

Larry G Strieff MD Medical Corporation

🇺🇸

Oakland, California, United States

Sutter Solano Medical Center

🇺🇸

Vallejo, California, United States

El Camino Hospital

🇺🇸

Mountain View, California, United States

Valley Medical Oncology Consultants-Fremont

🇺🇸

Fremont, California, United States

Marin General Hospital

🇺🇸

Greenbrae, California, United States

Bay Area Breast Surgeons Inc

🇺🇸

Oakland, California, United States

Kaiser Permanente-Redwood City

🇺🇸

Redwood City, California, United States

Contra Costa Regional Medical Center

🇺🇸

Martinez, California, United States

Mills - Peninsula Hospitals

🇺🇸

Burlingame, California, United States

Tahoe Forest Cancer Center

🇺🇸

Truckee, California, United States

Valley Medical Oncology Consultants

🇺🇸

Pleasanton, California, United States

North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

Kaiser Permanente-Roseville

🇺🇸

Roseville, California, United States

Kaiser Permanente-South San Francisco

🇺🇸

South San Francisco, California, United States

Salinas Valley Memorial

🇺🇸

Salinas, California, United States

Palo Alto Medical Foundation Heath Care

🇺🇸

Palo Alto, California, United States

Kaiser Permanente-Santa Rosa

🇺🇸

Santa Rosa, California, United States

Providence Hospital

🇺🇸

Mobile, Alabama, United States

Alta Bates Summit Medical Center-Herrick Campus

🇺🇸

Berkeley, California, United States

Eden Hospital Medical Center

🇺🇸

Castro Valley, California, United States

Sutter Cancer Research Consortium

🇺🇸

Novato, California, United States

Palo Alto Medical Foundation-Camino Division

🇺🇸

Mountain View, California, United States

Kaiser Permanente-Stockton

🇺🇸

Stockton, California, United States

Fremont - Rideout Cancer Center

🇺🇸

Marysville, California, United States

Saint Bernards Regional Medical Center

🇺🇸

Jonesboro, Arkansas, United States

Valley Care Health System - Pleasanton

🇺🇸

Pleasanton, California, United States

Doctors Medical Center- JC Robinson Regional Cancer Center

🇺🇸

San Pablo, California, United States

Community Hospital of Monterey Peninsula

🇺🇸

Monterey, California, United States

Kaiser Permanente-Vallejo

🇺🇸

Vallejo, California, United States

Exempla Lutheran Medical Center

🇺🇸

Wheat Ridge, Colorado, United States

Northside Hospital

🇺🇸

Atlanta, Georgia, United States

Well Star Cobb Hospital

🇺🇸

Austell, Georgia, United States

Pacific Cancer Institute of Maui

🇺🇸

Wailuku, Hawaii, United States

Kaiser Permanente-San Rafael

🇺🇸

San Rafael, California, United States

Holy Cross Hospital

🇺🇸

Fort Lauderdale, Florida, United States

Memorial Hospital Colorado Springs

🇺🇸

Colorado Springs, Colorado, United States

Memorial Health University Medical Center

🇺🇸

Savannah, Georgia, United States

Dekalb Medical Center

🇺🇸

Decatur, Georgia, United States

Porter Adventist Hospital

🇺🇸

Denver, Colorado, United States

Gwinnett Medical Center

🇺🇸

Lawrenceville, Georgia, United States

Georgia Regents University

🇺🇸

Augusta, Georgia, United States

Front Range Cancer Specialists

🇺🇸

Fort Collins, Colorado, United States

Saint Anthony Hospital

🇺🇸

Lakewood, Colorado, United States

Memorial Hospital

🇺🇸

Carthage, Illinois, United States

Mason District Hospital

🇺🇸

Havana, Illinois, United States

Hinsdale Hematology Oncology Associates Incorporated

🇺🇸

Hinsdale, Illinois, United States

Jupiter Medical Center

🇺🇸

Jupiter, Florida, United States

The Watson Clinic

🇺🇸

Lakeland, Florida, United States

Rush - Copley Medical Center

🇺🇸

Aurora, Illinois, United States

Good Samaritan Hospital

🇺🇸

Downers Grove, Illinois, United States

Piedmont Hospital

🇺🇸

Atlanta, Georgia, United States

Mayo Clinic in Florida

🇺🇸

Jacksonville, Florida, United States

Mount Sinai Medical Center CCOP

🇺🇸

Miami Beach, Florida, United States

Harbin Clinic Medical Oncology and Clinical Research

🇺🇸

Rome, Georgia, United States

University Cancer and Blood Center LLC

🇺🇸

Athens, Georgia, United States

Atlanta VA Medical Center

🇺🇸

Decatur, Georgia, United States

Hematology and Oncology Associates

🇺🇸

Chicago, Illinois, United States

John H Stroger Jr Hospital of Cook County

🇺🇸

Chicago, Illinois, United States

Swedish Covenant Hospital

🇺🇸

Chicago, Illinois, United States

Hematology Oncology Associates of Eastern Idaho

🇺🇸

Idaho Falls, Idaho, United States

Longmont United Hospital

🇺🇸

Longmont, Colorado, United States

Medical Center of Central Georgia

🇺🇸

Macon, Georgia, United States

Methodist Medical Center of Illinois

🇺🇸

Peoria, Illinois, United States

Valley Radiation Oncology

🇺🇸

Peru, Illinois, United States

Illinois CancerCare Galesburg

🇺🇸

Galesburg, Illinois, United States

Porubcin, Michael MD (UIA Investigator)

🇺🇸

Moline, Illinois, United States

Hopedale Medical Complex - Hospital

🇺🇸

Hopedale, Illinois, United States

Saint Margaret's Hospital

🇺🇸

Spring Valley, Illinois, United States

Eureka Hospital

🇺🇸

Eureka, Illinois, United States

Galesburg Cottage Hospital

🇺🇸

Galesburg, Illinois, United States

Illinois CancerCare-Peoria

🇺🇸

Peoria, Illinois, United States

OSF Saint Francis Medical Center

🇺🇸

Peoria, Illinois, United States

Western Illinois Cancer Treatment Center

🇺🇸

Galesburg, Illinois, United States

Sharis, Christine M MD (UIA Investigator)

🇺🇸

Moline, Illinois, United States

Bromenn Regional Medical Center

🇺🇸

Normal, Illinois, United States

Pekin Hospital

🇺🇸

Pekin, Illinois, United States

Midwest Center for Hematology Oncology

🇺🇸

Joliet, Illinois, United States

North Shore Hematology Oncology

🇺🇸

Libertyville, Illinois, United States

Decatur Memorial Hospital

🇺🇸

Decatur, Illinois, United States

Vigliotti, Antonio, P.G. M.D. (UIA Investigator)

🇺🇸

Moline, Illinois, United States

NorthShore University HealthSystem-Evanston Hospital

🇺🇸

Evanston, Illinois, United States

Mcdonough District Hospital

🇺🇸

Macomb, Illinois, United States

Perry Memorial Hospital

🇺🇸

Princeton, Illinois, United States

OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC

🇺🇸

Peoria, Illinois, United States

Illinois Oncology Research Association CCOP

🇺🇸

Peoria, Illinois, United States

Good Samaritan Regional Health Center

🇺🇸

Mount Vernon, Illinois, United States

Illinois Cancer Specialists-Niles

🇺🇸

Niles, Illinois, United States

Carle Clinic-Urbana Main

🇺🇸

Urbana, Illinois, United States

Community Howard Regional Health

🇺🇸

Kokomo, Indiana, United States

Constantinou, Costas L MD (UIA Investigator)

🇺🇸

Bettendorf, Iowa, United States

Medical Oncology and Hematology Associates-West Des Moines

🇺🇸

Clive, Iowa, United States

Hutchinson Area Health Care

🇺🇸

Hutchinson, Minnesota, United States

Cancer Center of Kansas - Salina

🇺🇸

Salina, Kansas, United States

Unity Hospital

🇺🇸

Fridley, Minnesota, United States

Cancer Center of Kansas - Pratt

🇺🇸

Pratt, Kansas, United States

Holland Community Hospital

🇺🇸

Holland, Michigan, United States

State University of New York Downstate Medical Center

🇺🇸

Brooklyn, New York, United States

Saint John's Hospital - Healtheast

🇺🇸

Maplewood, Minnesota, United States

New York University Langone Medical Center

🇺🇸

New York, New York, United States

Carolinas Medical Center

🇺🇸

Charlotte, North Carolina, United States

Wayne Radiation Oncology

🇺🇸

Goldsboro, North Carolina, United States

Sanford Bismarck Medical Center

🇺🇸

Bismarck, North Dakota, United States

Veterans Affairs Western New York Health Care System-Buffalo

🇺🇸

Buffalo, New York, United States

Columbia University Medical Center

🇺🇸

New York, New York, United States

Mission Hospital-Memorial Campus

🇺🇸

Asheville, North Carolina, United States

Community General Hospital

🇺🇸

Syracuse, New York, United States

Saint Joseph's Hospital - Healtheast

🇺🇸

Saint Paul, Minnesota, United States

Park Nicollet Clinic - Saint Louis Park

🇺🇸

Saint Louis Park, Minnesota, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

Grant Medical Center

🇺🇸

Columbus, Ohio, United States

Wayne Memorial Hospital

🇺🇸

Goldsboro, North Carolina, United States

Presbyterian Kaseman Hospital

🇺🇸

Albuquerque, New Mexico, United States

Carolinas Medical Center - Northeast

🇺🇸

Concord, North Carolina, United States

Mercy Medical Center

🇺🇸

Canton, Ohio, United States

Hematology Oncology Associates

🇺🇸

Albuquerque, New Mexico, United States

Rutherford Hospital

🇺🇸

Rutherfordton, North Carolina, United States

Kings County Hospital

🇺🇸

Brooklyn, New York, United States

State University of New York Upstate Medical University

🇺🇸

Syracuse, New York, United States

Hematology Oncology Associates of Central New York PC-East Syracuse

🇺🇸

East Syracuse, New York, United States

Altru Cancer Center

🇺🇸

Grand Forks, North Dakota, United States

Orange Regional Medical Center

🇺🇸

Middletown, New York, United States

Glens Falls Hospital

🇺🇸

Glens Falls, New York, United States

University Hospital of Brooklyn

🇺🇸

Brooklyn, New York, United States

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center

🇺🇸

Columbus, Ohio, United States

Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

Good Samaritan Hospital - Dayton

🇺🇸

Dayton, Ohio, United States

Aultman Health Foundation

🇺🇸

Canton, Ohio, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

Wilson Medical Center

🇺🇸

Wilson, North Carolina, United States

Mary Rutan Hospital

🇺🇸

Bellefontaine, Ohio, United States

Mount Carmel Health Center West

🇺🇸

Columbus, Ohio, United States

Sanford Clinic North-Fargo

🇺🇸

Fargo, North Dakota, United States

North Coast Cancer Care-Clyde

🇺🇸

Clyde, Ohio, United States

Columbus CCOP

🇺🇸

Columbus, Ohio, United States

Saint Mary's Hospital

🇺🇸

Green Bay, Wisconsin, United States

Cleveland Clinic Cancer Center Independence

🇺🇸

Independence, Ohio, United States

Fairfield Medical Center

🇺🇸

Lancaster, Ohio, United States

Springfield Regional Medical Center

🇺🇸

Springfield, Ohio, United States

University of Pennsylvania/Abramson Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Bryn Mawr Hospital

🇺🇸

Bryn Mawr, Pennsylvania, United States

Multicare Health System

🇺🇸

Tacoma, Washington, United States

Rockwood Clinic

🇺🇸

Spokane, Washington, United States

PeaceHealth Southwest Medical Center

🇺🇸

Vancouver, Washington, United States

Geisinger Wyoming Valley

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Lankenau Hospital

🇺🇸

Wynnewood, Pennsylvania, United States

Saint Paul Hospital

🇺🇸

Dallas, Texas, United States

Northwest CCOP

🇺🇸

Tacoma, Washington, United States

Cancer Care Northwest - Spokane South

🇺🇸

Spokane, Washington, United States

Saint Clare Hospital

🇺🇸

Tacoma, Washington, United States

Dixie Medical Center Regional Cancer Center

🇺🇸

Saint George, Utah, United States

PeaceHealth Saint Joseph Medical Center

🇺🇸

Bellingham, Washington, United States

Columbia Basin Hematology and Oncology PLLC

🇺🇸

Kennewick, Washington, United States

Mayo Clinic Health System-Franciscan Healthcare

🇺🇸

La Crosse, Wisconsin, United States

Thunder Bay Regional Health Science Centre

🇨🇦

Thunder Bay, Ontario, Canada

Mount Sinai Hospital Medical Center

🇺🇸

Chicago, Illinois, United States

Northwestern University

🇺🇸

Chicago, Illinois, United States

Jesse Brown Veterans Affairs Medical Center

🇺🇸

Chicago, Illinois, United States

Rush University Medical Center

🇺🇸

Chicago, Illinois, United States

Mercy Hospital and Medical Center

🇺🇸

Chicago, Illinois, United States

Resurrection Healthcare

🇺🇸

Chicago, Illinois, United States

University of Chicago

🇺🇸

Chicago, Illinois, United States

The Polyclinic

🇺🇸

Seattle, Washington, United States

Swedish Medical Center-First Hill

🇺🇸

Seattle, Washington, United States

University of Washington Medical Center

🇺🇸

Seattle, Washington, United States

University Medical Center of Southern Nevada

🇺🇸

Las Vegas, Nevada, United States

University of California At San Diego

🇺🇸

San Diego, California, United States

The Christ Hospital

🇺🇸

Cincinnati, Ohio, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center

🇺🇸

Miami, Florida, United States

Saint Vincent Hospital and Health Services

🇺🇸

Indianapolis, Indiana, United States

University of Iowa Hospitals and Clinics

🇺🇸

Iowa City, Iowa, United States

Mercy Medical Center - North Iowa

🇺🇸

Mason City, Iowa, United States

East Bay Radiation Oncology Center

🇺🇸

Castro Valley, California, United States

Valley Medical Oncology Consultants-Castro Valley

🇺🇸

Castro Valley, California, United States

Kaiser Permanente, Fremont

🇺🇸

Fremont, California, United States

Cancer Care Associates of Fresno Medical Group Inc

🇺🇸

Fresno, California, United States

Saint Jude Medical Center

🇺🇸

Fullerton, California, United States

Glendale Memorial Hospital and Health Center

🇺🇸

Glendale, California, United States

University of Southern California/Norris Cancer Center

🇺🇸

Los Angeles, California, United States

Kaiser Permanente, Hayward

🇺🇸

Hayward, California, United States

Saint Rose Hospital

🇺🇸

Hayward, California, United States

Highland General Hospital

🇺🇸

Oakland, California, United States

Desert Regional Medical Center

🇺🇸

Palm Springs, California, United States

Kaiser Permanente-Richmond

🇺🇸

Richmond, California, United States

Kaiser Permanente-Santa Teresa-San Jose

🇺🇸

San Jose, California, United States

Kaiser Permanente-Walnut Creek

🇺🇸

Walnut Creek, California, United States

Saint Mary's Hospital and Regional Medical Center

🇺🇸

Grand Junction, Colorado, United States

North Suburban Medical Center

🇺🇸

Thornton, Colorado, United States

Saint Mary Corwin Medical Center

🇺🇸

Pueblo, Colorado, United States

Beebe Medical Center

🇺🇸

Lewes, Delaware, United States

Cancer Specialists of North Florida-Orange Park

🇺🇸

Orange Park, Florida, United States

Atlanta Regional CCOP

🇺🇸

Atlanta, Georgia, United States

Saint Joseph's Hospital of Atlanta

🇺🇸

Atlanta, Georgia, United States

Wellstar Kennestone Hospital

🇺🇸

Marietta, Georgia, United States

Pali Momi Medical Center

🇺🇸

'Aiea, Hawaii, United States

Saint Anthony's Health

🇺🇸

Alton, Illinois, United States

Graham Hospital Association

🇺🇸

Canton, Illinois, United States

Saint Joseph Medical Center

🇺🇸

Tacoma, Washington, United States

Elmhurst Memorial Hospital

🇺🇸

Elmhurst, Illinois, United States

Saint Francis Hospital

🇺🇸

Federal Way, Washington, United States

Joliet Oncology-Hematology Associates Limited

🇺🇸

Joliet, Illinois, United States

Kewanee Hospital

🇺🇸

Kewanee, Illinois, United States

Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

Garneau, Stewart C MD (UIA Investigator)

🇺🇸

Moline, Illinois, United States

Stoffel, Thomas J MD (UIA Investigator)

🇺🇸

Moline, Illinois, United States

Edward Hospital/Cancer Center

🇺🇸

Naperville, Illinois, United States

Illinois CancerCare-Ottawa Clinic

🇺🇸

Ottawa, Illinois, United States

Community Cancer Center Foundation

🇺🇸

Normal, Illinois, United States

Ottawa Regional Hospital and Healthcare Center

🇺🇸

Ottawa, Illinois, United States

Pekin Cancer Treatment Center

🇺🇸

Pekin, Illinois, United States

Swedish American Hospital

🇺🇸

Rockford, Illinois, United States

Hematology Oncology Associates of Illinois - Skokie

🇺🇸

Skokie, Illinois, United States

Saint Francis Hospital and Health Centers

🇺🇸

Beech Grove, Indiana, United States

Franciscan Saint Anthony Health-Michigan City

🇺🇸

Michigan City, Indiana, United States

Saint Joseph Regional Medical Center-Mishawaka

🇺🇸

Mishawaka, Indiana, United States

IU Health Ball Memorial Hospital

🇺🇸

Muncie, Indiana, United States

Oncology Hematology Associates of Southwest Indiana

🇺🇸

Newburgh, Indiana, United States

Memorial Hospital of South Bend

🇺🇸

South Bend, Indiana, United States

Northern Indiana Cancer Research Consortium

🇺🇸

South Bend, Indiana, United States

McFarland Clinic PC-William R Bliss Cancer Center

🇺🇸

Ames, Iowa, United States

Cedar Rapids Oncology Association

🇺🇸

Cedar Rapids, Iowa, United States

Oncology Associates at Mercy Medical Center

🇺🇸

Cedar Rapids, Iowa, United States

Genesis Medical Center - East Campus

🇺🇸

Davenport, Iowa, United States

Genesis Medical Center - West Campus

🇺🇸

Davenport, Iowa, United States

Siouxland Regional Cancer Center

🇺🇸

Sioux City, Iowa, United States

Siouxland Hematology Oncology Associates

🇺🇸

Sioux City, Iowa, United States

Mercy Medical Center-Sioux City

🇺🇸

Sioux City, Iowa, United States

Cedar Valley Medical Specialists

🇺🇸

Waterloo, Iowa, United States

Saint Luke's Regional Medical Center

🇺🇸

Sioux City, Iowa, United States

Covenant Medical Center

🇺🇸

Waterloo, Iowa, United States

Lawrence Memorial Hospital

🇺🇸

Lawrence, Kansas, United States

Cancer Center of Kansas - Parsons

🇺🇸

Parsons, Kansas, United States

Saint Charles Medical Center-Bend

🇺🇸

Bend, Oregon, United States

Associates In Womens Health

🇺🇸

Wichita, Kansas, United States

Eastern Maine Medical Center

🇺🇸

Bangor, Maine, United States

Saint Mary's Regional Medical Center

🇺🇸

Lewiston, Maine, United States

Maine Medical Center- Scarborough Campus

🇺🇸

Scarborough, Maine, United States

Franklin Square Hospital Center

🇺🇸

Baltimore, Maryland, United States

Memorial Hospital at Easton - Shore Regional Cancer Center

🇺🇸

Easton, Maryland, United States

Abbott-Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

Virginia Piper Cancer Institute

🇺🇸

Minneapolis, Minnesota, United States

Minneapolis Veterans Medical Center

🇺🇸

Minneapolis, Minnesota, United States

Eastern Cooperative Oncology Group

🇺🇸

Boston, Massachusetts, United States

Union Hospital of Cecil County

🇺🇸

Elkton, Maryland, United States

Caritas Saint Elizabeth's Medical Center

🇺🇸

Brighton, Massachusetts, United States

Lahey Hospital and Medical Center

🇺🇸

Burlington, Massachusetts, United States

Simonds-Sinon Regional Cancer Center

🇺🇸

Fitchburg, Massachusetts, United States

Berkshire Hematology Oncology PC

🇺🇸

Pittsfield, Massachusetts, United States

University of Massachusetts Medical School

🇺🇸

Worcester, Massachusetts, United States

Bixby Medical Center

🇺🇸

Adrian, Michigan, United States

Hickman Cancer Center

🇺🇸

Adrian, Michigan, United States

Bronson Battle Creek

🇺🇸

Battle Creek, Michigan, United States

Spectrum Health Big Rapids Hospital

🇺🇸

Big Rapids, Michigan, United States

Oakwood Hospital

🇺🇸

Dearborn, Michigan, United States

Green Bay Oncology - Escanaba

🇺🇸

Escanaba, Michigan, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

Genesys Regional Medical Center-West Flint Campus

🇺🇸

Flint, Michigan, United States

Grand Rapids Clinical Oncology Program

🇺🇸

Grand Rapids, Michigan, United States

Mercy Health Saint Mary's

🇺🇸

Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus

🇺🇸

Grand Rapids, Michigan, United States

Green Bay Oncology - Iron Mountain

🇺🇸

Iron Mountain, Michigan, United States

Sparrow Hospital

🇺🇸

Lansing, Michigan, United States

Saint Mary Mercy Hospital

🇺🇸

Livonia, Michigan, United States

Allegiance Health

🇺🇸

Jackson, Michigan, United States

Marquette General Hospital

🇺🇸

Marquette, Michigan, United States

Community Cancer Center of Monroe

🇺🇸

Monroe, Michigan, United States

Mercy Memorial Hospital

🇺🇸

Monroe, Michigan, United States

Mercy Health Partners-Hackley Campus

🇺🇸

Muskegon, Michigan, United States

Mercy Health Mercy Campus

🇺🇸

Muskegon, Michigan, United States

Saint Joseph Mercy Oakland

🇺🇸

Pontiac, Michigan, United States

Saint Joseph Mercy Port Huron

🇺🇸

Port Huron, Michigan, United States

Saint Mary's of Michigan

🇺🇸

Saginaw, Michigan, United States

Lakeland Hospital

🇺🇸

Saint Joseph, Michigan, United States

William Beaumont Hospital-Royal Oak

🇺🇸

Royal Oak, Michigan, United States

Munson Medical Center

🇺🇸

Traverse City, Michigan, United States

Sanford Clinic North-Bemidgi

🇺🇸

Bemidji, Minnesota, United States

Metro Health Hospital

🇺🇸

Wyoming, Michigan, United States

Fairview Ridges Hospital

🇺🇸

Burnsville, Minnesota, United States

Mercy Hospital

🇺🇸

Scranton, Pennsylvania, United States

Essentia Health Duluth Clinic CCOP

🇺🇸

Duluth, Minnesota, United States

Essentia Health Saint Mary's Medical Center

🇺🇸

Duluth, Minnesota, United States

Miller-Dwan Hospital

🇺🇸

Duluth, Minnesota, United States

Fairview-Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Meeker County Memorial Hospital

🇺🇸

Litchfield, Minnesota, United States

Mayo Clinic Health Systems-Mankato

🇺🇸

Mankato, Minnesota, United States

Hennepin County Medical Center

🇺🇸

Minneapolis, Minnesota, United States

North Memorial Medical Health Center

🇺🇸

Robbinsdale, Minnesota, United States

Metro-Minnesota CCOP

🇺🇸

Saint Louis Park, Minnesota, United States

Regions Hospital

🇺🇸

Saint Paul, Minnesota, United States

United Hospital

🇺🇸

Saint Paul, Minnesota, United States

Saint Francis Regional Medical Center

🇺🇸

Shakopee, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Rice Memorial Hospital

🇺🇸

Willmar, Minnesota, United States

Minnesota Oncology and Hematology PA-Woodbury

🇺🇸

Woodbury, Minnesota, United States

Southeast Missouri Hospital

🇺🇸

Cape Girardeau, Missouri, United States

Woodwinds Health Campus

🇺🇸

Woodbury, Minnesota, United States

Saint Francis Medical Center

🇺🇸

Cape Girardeau, Missouri, United States

Freeman Health System

🇺🇸

Joplin, Missouri, United States

Mercy Hospital-Joplin

🇺🇸

Joplin, Missouri, United States

Saint Louis Cancer and Breast Institute-South City

🇺🇸

Saint Louis, Missouri, United States

Saint Louis University Hospital

🇺🇸

Saint Louis, Missouri, United States

Missouri Baptist Medical Center

🇺🇸

Saint Louis, Missouri, United States

Center for Cancer Care and Research

🇺🇸

Saint Louis, Missouri, United States

Saint John's Mercy Medical Center

🇺🇸

Saint Louis, Missouri, United States

Saint Louis-Cape Girardeau CCOP

🇺🇸

Saint Louis, Missouri, United States

Mercy Hospital Springfield

🇺🇸

Springfield, Missouri, United States

CoxHealth South Hospital

🇺🇸

Springfield, Missouri, United States

Montana Cancer Consortium CCOP

🇺🇸

Billings, Montana, United States

Northern Rockies Radiation Oncology Center

🇺🇸

Billings, Montana, United States

Saint Vincent Healthcare

🇺🇸

Billings, Montana, United States

Hematology-Oncology Centers of the Northern Rockies PC

🇺🇸

Billings, Montana, United States

Billings Clinic

🇺🇸

Billings, Montana, United States

Deaconess Medical Center

🇺🇸

Billings, Montana, United States

Bozeman Deaconess Cancer Center

🇺🇸

Bozeman, Montana, United States

Bozeman Deaconess Hospital

🇺🇸

Bozeman, Montana, United States

Benefis Healthcare- Sletten Cancer Institute

🇺🇸

Great Falls, Montana, United States

Saint James Community Hospital and Cancer Treatment Center

🇺🇸

Butte, Montana, United States

Berdeaux, Donald MD (UIA Investigator)

🇺🇸

Great Falls, Montana, United States

Great Falls Clinic

🇺🇸

Great Falls, Montana, United States

Northern Montana Hospital

🇺🇸

Havre, Montana, United States

Saint Peter's Community Hospital

🇺🇸

Helena, Montana, United States

Kalispell Medical Oncology

🇺🇸

Kalispell, Montana, United States

Kalispell Regional Medical Center

🇺🇸

Kalispell, Montana, United States

Community Medical Hospital

🇺🇸

Missoula, Montana, United States

Saint Patrick Hospital - Community Hospital

🇺🇸

Missoula, Montana, United States

Guardian Oncology and Center for Wellness

🇺🇸

Missoula, Montana, United States

Nebraska Cancer Research Center

🇺🇸

Lincoln, Nebraska, United States

Exeter Hospital

🇺🇸

Exeter, New Hampshire, United States

Nevada Cancer Research Foundation CCOP

🇺🇸

Las Vegas, Nevada, United States

Cheshire Medical Center-Dartmouth-Hitchcock Keene

🇺🇸

Keene, New Hampshire, United States

Elliot Hospital

🇺🇸

Manchester, New Hampshire, United States

Ocean Medical Center

🇺🇸

Brick, New Jersey, United States

Cooper Hospital University Medical Center

🇺🇸

Camden, New Jersey, United States

Monmouth Medical Center

🇺🇸

Long Branch, New Jersey, United States

Cancer Institute of New Jersey At Hamilton

🇺🇸

Hamilton, New Jersey, United States

New Mexico Cancer Care Associates

🇺🇸

Santa Fe, New Mexico, United States

Weill Medical College of Cornell University

🇺🇸

New York, New York, United States

Toledo Clinic Cancer Centers-Bowling Green

🇺🇸

Bowling Green, Ohio, United States

Doctors Hospital

🇺🇸

Columbus, Ohio, United States

Grandview Hospital

🇺🇸

Dayton, Ohio, United States

Dayton CCOP

🇺🇸

Dayton, Ohio, United States

Samaritan North Health Center

🇺🇸

Dayton, Ohio, United States

Veteran Affairs Medical Center

🇺🇸

Dayton, Ohio, United States

Grady Memorial Hospital

🇺🇸

Delaware, Ohio, United States

Hematology Oncology Center Incorporated

🇺🇸

Elyria, Ohio, United States

Blanchard Valley Hospital

🇺🇸

Findlay, Ohio, United States

Atrium Medical Center-Middletown Regional Hospital

🇺🇸

Franklin, Ohio, United States

Fremont Memorial Hospital

🇺🇸

Fremont, Ohio, United States

Wayne Hospital

🇺🇸

Greenville, Ohio, United States

Cole, Sharon, K. M.D. (UIA Investigator)

🇺🇸

Kenton, Ohio, United States

Kettering Medical Center

🇺🇸

Kettering, Ohio, United States

Saint Luke's Hospital

🇺🇸

Maumee, Ohio, United States

Lima Memorial Hospital

🇺🇸

Lima, Ohio, United States

Marietta Memorial Hospital

🇺🇸

Marietta, Ohio, United States

Toledo Clinic Cancer Centers-Maumee

🇺🇸

Maumee, Ohio, United States

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center

🇺🇸

Maumee, Ohio, United States

Licking Memorial Hospital

🇺🇸

Newark, Ohio, United States

Saint Charles Hospital

🇺🇸

Oregon, Ohio, United States

Toledo Clinic Cancer Centers-Oregon

🇺🇸

Oregon, Ohio, United States

Firelands Regional Medical Center

🇺🇸

Sandusky, Ohio, United States

North Coast Cancer Care

🇺🇸

Sandusky, Ohio, United States

Flower Hospital

🇺🇸

Sylvania, Ohio, United States

Mercy Hospital of Tiffin

🇺🇸

Tiffin, Ohio, United States

The Toledo Hospital/Toledo Children's Hospital

🇺🇸

Toledo, Ohio, United States

Saint Vincent Mercy Medical Center

🇺🇸

Toledo, Ohio, United States

Mercy Saint Anne Hospital

🇺🇸

Toledo, Ohio, United States

University of Toledo

🇺🇸

Toledo, Ohio, United States

Toledo Community Hospital Oncology Program CCOP

🇺🇸

Toledo, Ohio, United States

Stark, Michael, Edward. M.D. (UIA Investigator)

🇺🇸

Toledo, Ohio, United States

Toledo Clinic Cancer Centers-Toledo

🇺🇸

Toledo, Ohio, United States

Upper Valley Medical Center

🇺🇸

Troy, Ohio, United States

Fulton County Health Center

🇺🇸

Wauseon, Ohio, United States

Cleveland Clinic Wooster Specialty Center

🇺🇸

Wooster, Ohio, United States

Saint Ann's Hospital

🇺🇸

Westerville, Ohio, United States

Clinton Memorial Hospital

🇺🇸

Wilmington, Ohio, United States

Greene Memorial Hospital

🇺🇸

Xenia, Ohio, United States

Natalie Warren Bryant Cancer Center at Saint Francis

🇺🇸

Tulsa, Oklahoma, United States

Genesis HealthCare System

🇺🇸

Zanesville, Ohio, United States

Providence Milwaukie Hospital

🇺🇸

Milwaukie, Oregon, United States

Abington Memorial Hospital

🇺🇸

Abington, Pennsylvania, United States

Lehigh Valley Hospital

🇺🇸

Allentown, Pennsylvania, United States

Saint Luke's University Hospital-Bethlehem Campus

🇺🇸

Bethlehem, Pennsylvania, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Paoli Memorial Hospital

🇺🇸

Paoli, Pennsylvania, United States

Riddle Hospital

🇺🇸

Media, Pennsylvania, United States

Pennsylvania Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital

🇺🇸

Philadelphia, Pennsylvania, United States

Albert Einstein Medical Center

🇺🇸

Philadelphia, Pennsylvania, United States

University of Pittsburgh

🇺🇸

Pittsburgh, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Pottstown Memorial Medical Center

🇺🇸

Pottstown, Pennsylvania, United States

Hematology and Oncology Associates of North East Pennsylvania

🇺🇸

Scranton, Pennsylvania, United States

Scranton Hematology Oncology

🇺🇸

Scranton, Pennsylvania, United States

Geisinger Medical Group

🇺🇸

State College, Pennsylvania, United States

Reading Hospital

🇺🇸

West Reading, Pennsylvania, United States

Mainline Health CCOP

🇺🇸

Wynnewood, Pennsylvania, United States

WellSpan Health-York Hospital

🇺🇸

York, Pennsylvania, United States

Hematology and Oncology Associates of Rhode Island Inc

🇺🇸

Cranston, Rhode Island, United States

Kent County Hospital

🇺🇸

Warwick, Rhode Island, United States

AnMed Health Hospital

🇺🇸

Anderson, South Carolina, United States

McLeod Regional Medical Center

🇺🇸

Florence, South Carolina, United States

Greenville Health System Cancer Institute/Greenville CCOP

🇺🇸

Greenville, South Carolina, United States

Spartanburg Regional Medical Center

🇺🇸

Spartanburg, South Carolina, United States

Sanford USD Medical Center - Sioux Falls

🇺🇸

Sioux Falls, South Dakota, United States

Wellmont Holston Valley Hospital and Medical Center

🇺🇸

Kingsport, Tennessee, United States

Thompson Cancer Survival Center

🇺🇸

Knoxville, Tennessee, United States

University of Tennessee - Memphis

🇺🇸

Memphis, Tennessee, United States

Parkland Memorial Hospital

🇺🇸

Dallas, Texas, United States

Zale Lipshy University Hospital

🇺🇸

Dallas, Texas, United States

University of Texas Southwestern Medical Center

🇺🇸

Dallas, Texas, United States

Texas Tech University Health Sciences Center

🇺🇸

Lubbock, Texas, United States

Scott and White Memorial Hospital

🇺🇸

Temple, Texas, United States

American Fork Hospital

🇺🇸

American Fork, Utah, United States

Cottonwood Hospital Medical Center

🇺🇸

Murray, Utah, United States

Sandra L Maxwell Cancer Center

🇺🇸

Cedar City, Utah, United States

Logan Regional Hospital

🇺🇸

Logan, Utah, United States

Intermountain Medical Center

🇺🇸

Murray, Utah, United States

Utah Valley Regional Medical Center

🇺🇸

Provo, Utah, United States

McKay-Dee Hospital Center

🇺🇸

Ogden, Utah, United States

LDS Hospital

🇺🇸

Salt Lake City, Utah, United States

University of Vermont

🇺🇸

Burlington, Vermont, United States

Martha Jefferson Hospital

🇺🇸

Charlottesville, Virginia, United States

University of Virginia

🇺🇸

Charlottesville, Virginia, United States

Fredericksburg Oncology Inc

🇺🇸

Fredericksburg, Virginia, United States

Virginia Oncology Associates-Hampton

🇺🇸

Hampton, Virginia, United States

Southwest VA Regional Cancer Center

🇺🇸

Norton, Virginia, United States

Rockingham Memorial Hospital Hahn Cancer Center

🇺🇸

Harrisonburg, Virginia, United States

Lynchburg Hematology-Oncology Clinic

🇺🇸

Lynchburg, Virginia, United States

Auburn Regional Medical Center

🇺🇸

Auburn, Washington, United States

Harrison HealthPartners Hematology and Oncology-Bremerton

🇺🇸

Bremerton, Washington, United States

Providence Centralia Hospital

🇺🇸

Centralia, Washington, United States

Providence - Saint Peter Hospital

🇺🇸

Olympia, Washington, United States

Good Samaritan Community Hospital

🇺🇸

Puyallup, Washington, United States

Minor and James Medical PLLC

🇺🇸

Seattle, Washington, United States

Group Health Cooperative-Seattle

🇺🇸

Seattle, Washington, United States

Allenmore Hospital

🇺🇸

Tacoma, Washington, United States

Madigan Army Medical Center

🇺🇸

Tacoma, Washington, United States

Compass Oncology Vancouver

🇺🇸

Vancouver, Washington, United States

Aurora Cancer Care-Southern Lakes

🇺🇸

Elkhorn, Wisconsin, United States

Marshfield Clinic Cancer Center at Sacred Heart

🇺🇸

Eau Claire, Wisconsin, United States

Sacred Heart Hospital

🇺🇸

Eau Claire, Wisconsin, United States

Agnesian Cancer Center

🇺🇸

Fond Du Lac, Wisconsin, United States

Aurora Cancer Care-Glendale

🇺🇸

Glendale, Wisconsin, United States

Green Bay Oncology at Saint Vincent Hospital

🇺🇸

Green Bay, Wisconsin, United States

Green Bay Oncology Limited at Saint Mary's Hospital

🇺🇸

Green Bay, Wisconsin, United States

Saint Vincent Hospital

🇺🇸

Green Bay, Wisconsin, United States

Mercy Health System

🇺🇸

Janesville, Wisconsin, United States

Bay Area Medical Center

🇺🇸

Marinette, Wisconsin, United States

Marshfield Clinic

🇺🇸

Marshfield, Wisconsin, United States

Saint Joseph's Hospital

🇺🇸

Marshfield, Wisconsin, United States

Marshfield Clinic-Minocqua Center

🇺🇸

Minocqua, Wisconsin, United States

Green Bay Oncology - Oconto Falls

🇺🇸

Oconto Falls, Wisconsin, United States

Marshfield Clinic at James Beck Cancer Center

🇺🇸

Rhinelander, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan

🇺🇸

Sheboygan, Wisconsin, United States

Marshfield Clinic-Rice Lake Center

🇺🇸

Rice Lake, Wisconsin, United States

Saint Michael's Hospital

🇨🇦

Toronto, Ontario, Canada

Green Bay Oncology - Sturgeon Bay

🇺🇸

Sturgeon Bay, Wisconsin, United States

Marshfield Clinic-Wausau Center

🇺🇸

Wausau, Wisconsin, United States

Marshfield Clinic - Weston Center

🇺🇸

Weston, Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center

🇺🇸

Wisconsin Rapids, Wisconsin, United States

Atlantic Health Sciences Corporation-Saint John Regional Hospital

🇨🇦

Saint John, New Brunswick, Canada

Cross Cancer Institute

🇨🇦

Edmonton, Alberta, Canada

London Regional Cancer Program

🇨🇦

London, Ontario, Canada

Grand River Regional Cancer Centre at Grand River Hospital

🇨🇦

Kitchener, Ontario, Canada

Credit Valley Hospital

🇨🇦

Mississauga, Ontario, Canada

Lakeridge Health Oshawa

🇨🇦

Oshawa, Ontario, Canada

Ottawa Health Research Institute-General Division

🇨🇦

Ottawa, Ontario, Canada

University Health Network-Princess Margaret Hospital

🇨🇦

Toronto, Ontario, Canada

CSSS Champlain-Charles Le Moyne

🇨🇦

Greenfield Park, Quebec, Canada

CHUQ - Pavilion Hotel-Dieu de Quebec

🇨🇦

Quebec City, Quebec, Canada

Allan Blair Cancer Centre

🇨🇦

Regina, Saskatchewan, Canada

Saskatoon Cancer Centre

🇨🇦

Saskatoon, Saskatchewan, Canada

Instituto Nacional de Enfermedades Neoplasicas

🇵🇪

Lima, Peru

I Gonzales Martinez-Oncologic Hospital

🇵🇷

San Juan, Puerto Rico

San Juan City Hospital

🇵🇷

San Juan, Puerto Rico

Kaiser Permanente-San Francisco

🇺🇸

San Francisco, California, United States

California Pacific Medical Center

🇺🇸

San Francisco, California, United States

Nashville Oncology Associates PC

🇺🇸

Nashville, Tennessee, United States

Tennessee Oncology PLLC- Centennial Medical Center

🇺🇸

Nashville, Tennessee, United States

Meharry Medical College

🇺🇸

Nashville, Tennessee, United States

Vanderbilt-Ingram Cancer Center

🇺🇸

Nashville, Tennessee, United States

Intermountain Health Care

🇺🇸

Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah

🇺🇸

Salt Lake City, Utah, United States

Cancer Center of Kansas - Main Office

🇺🇸

Wichita, Kansas, United States

Stormont-Vail Regional Health Center

🇺🇸

Topeka, Kansas, United States

Cancer Center of Kansas - Dodge City

🇺🇸

Dodge City, Kansas, United States

Cancer Center of Kansas - Newton

🇺🇸

Newton, Kansas, United States

Via Christi Regional Medical Center

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas - Chanute

🇺🇸

Chanute, Kansas, United States

Olathe Cancer Center

🇺🇸

Olathe, Kansas, United States

Hospital District Sixth of Harper County

🇺🇸

Anthony, Kansas, United States

Maui Memorial Medical Center

🇺🇸

Wailuku, Hawaii, United States

Saint Alexius Medical Center

🇺🇸

Bismarck, North Dakota, United States

Cancer Center of Kansas-Independence

🇺🇸

Independence, Kansas, United States

Cancer Center of Kansas-Wichita Medical Arts Tower

🇺🇸

Wichita, Kansas, United States

Cancer Center of Kansas - Wellington

🇺🇸

Wellington, Kansas, United States

Cancer Center of Kansas - Winfield

🇺🇸

Winfield, Kansas, United States

Bismarck Cancer Center

🇺🇸

Bismarck, North Dakota, United States

Cancer Center of Kansas-Kingman

🇺🇸

Kingman, Kansas, United States

Mid Dakota Clinic

🇺🇸

Bismarck, North Dakota, United States

Sanford Medical Center-Fargo

🇺🇸

Fargo, North Dakota, United States

Cancer Center of Kansas - Fort Scott

🇺🇸

Fort Scott, Kansas, United States

Welch Cancer Center

🇺🇸

Sheridan, Wyoming, United States

Washington Hospital Center

🇺🇸

Washington, District of Columbia, United States

Saint Luke's Mountain States Tumor Institute

🇺🇸

Boise, Idaho, United States

Eastern Connecticut Hematology and Oncology Associates

🇺🇸

Norwich, Connecticut, United States

Christiana Care Health System-Christiana Hospital

🇺🇸

Newark, Delaware, United States

Swedish Medical Center

🇺🇸

Englewood, Colorado, United States

Lombardi Comprehensive Cancer Center at Georgetown University

🇺🇸

Washington, District of Columbia, United States

Valley Hospital

🇺🇸

Ridgewood, New Jersey, United States

Mayo Clinic in Arizona

🇺🇸

Scottsdale, Arizona, United States

Providence Alaska Medical Center

🇺🇸

Anchorage, Alaska, United States

Portneuf Medical Center

🇺🇸

Pocatello, Idaho, United States

Rutgers Cancer Institute of New Jersey

🇺🇸

New Brunswick, New Jersey, United States

Mountainside Hospital

🇺🇸

Montclair, New Jersey, United States

Saint Alphonsus Regional Medical Center

🇺🇸

Boise, Idaho, United States

Overlook Hospital

🇺🇸

Summit, New Jersey, United States

Montana Cancer Specialists

🇺🇸

Missoula, Montana, United States

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County

🇺🇸

Mount Holly, New Jersey, United States

Virtua West Jersey Hospital Voorhees

🇺🇸

Voorhees, New Jersey, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

Sparta Cancer Treatment Center

🇺🇸

Sparta, New Jersey, United States

University of Cincinnati

🇺🇸

Cincinnati, Ohio, United States

Glacier Oncology PLLC

🇺🇸

Kalispell, Montana, United States

Newark Beth Israel Medical Center

🇺🇸

Newark, New Jersey, United States

Morristown Memorial Hospital

🇺🇸

Morristown, New Jersey, United States

Upstate Carolina CCOP

🇺🇸

Spartanburg, South Carolina, United States

MetroHealth Medical Center

🇺🇸

Cleveland, Ohio, United States

Medical X-Ray Center

🇺🇸

Sioux Falls, South Dakota, United States

Sanford Cancer Center-Oncology Clinic

🇺🇸

Sioux Falls, South Dakota, United States

Camden-Clark Memorial Hospital

🇺🇸

Parkersburg, West Virginia, United States

Kaiser Permanente

🇺🇸

Portland, Oregon, United States

Exempla Saint Joseph Hospital

🇺🇸

Denver, Colorado, United States

Presbyterian - Saint Lukes Medical Center - Health One

🇺🇸

Denver, Colorado, United States

Colorado Cancer Research Program CCOP

🇺🇸

Denver, Colorado, United States

Wayne State University/Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

Saint John Hospital and Medical Center

🇺🇸

Detroit, Michigan, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

Cancer Care Associates

🇺🇸

Oklahoma City, Oklahoma, United States

Providence Portland Medical Center

🇺🇸

Portland, Oregon, United States

Western Oncology Research Consortium

🇺🇸

Portland, Oregon, United States

Adventist Medical Center

🇺🇸

Portland, Oregon, United States

Providence Saint Vincent Medical Center

🇺🇸

Portland, Oregon, United States

Nebraska Methodist Hospital

🇺🇸

Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center

🇺🇸

Omaha, Nebraska, United States

Creighton University Medical Center

🇺🇸

Omaha, Nebraska, United States

University of Nebraska Medical Center

🇺🇸

Omaha, Nebraska, United States

Mayo Clinic

🇺🇸

Rochester, Minnesota, United States

Missouri Valley Cancer Consortium CCOP

🇺🇸

Omaha, Nebraska, United States

Alegent Health Immanuel Medical Center

🇺🇸

Omaha, Nebraska, United States

Medical Consultants Limited

🇺🇸

Milwaukee, Wisconsin, United States

Utah Cancer Specialists-Salt Lake City

🇺🇸

Salt Lake City, Utah, United States

The Medical Center of Aurora

🇺🇸

Aurora, Colorado, United States

Oncare Hawaii Inc-POB II

🇺🇸

Honolulu, Hawaii, United States

Queen's Medical Center

🇺🇸

Honolulu, Hawaii, United States

Straub Clinic and Hospital

🇺🇸

Honolulu, Hawaii, United States

Oncare Hawaii Inc-Kuakini

🇺🇸

Honolulu, Hawaii, United States

Highland Hospital

🇺🇸

Rochester, New York, United States

Interlakes Foundation Inc-Rochester

🇺🇸

Rochester, New York, United States

Mercy Capitol

🇺🇸

Des Moines, Iowa, United States

Iowa Methodist Medical Center

🇺🇸

Des Moines, Iowa, United States

Mercy Medical Center - Des Moines

🇺🇸

Des Moines, Iowa, United States

Iowa Lutheran Hospital

🇺🇸

Des Moines, Iowa, United States

Boulder Community Hospital

🇺🇸

Boulder, Colorado, United States

Penrose-Saint Francis Healthcare

🇺🇸

Colorado Springs, Colorado, United States

Rose Medical Center

🇺🇸

Denver, Colorado, United States

University of California at Davis Cancer Center

🇺🇸

Sacramento, California, United States

Kaiser Permanente-South Sacramento

🇺🇸

Sacramento, California, United States

Kaiser Permanente - Sacramento

🇺🇸

Sacramento, California, United States

Saint Joseph Mercy Hospital

🇺🇸

Ann Arbor, Michigan, United States

Michigan Cancer Research Consortium Community Clinical Oncology Program

🇺🇸

Ann Arbor, Michigan, United States

Illinois Valley Hospital

🇺🇸

Peru, Illinois, United States

Midwest Cancer Research Group Incorporated

🇺🇸

Skokie, Illinois, United States

Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

Edward H Kaplan MD and Associates

🇺🇸

Skokie, Illinois, United States

Carle Cancer Center

🇺🇸

Urbana, Illinois, United States

Reid Hospital and Health Care Services

🇺🇸

Richmond, Indiana, United States

IU Health La Porte Hospital

🇺🇸

La Porte, Indiana, United States

Elkhart General Hospital

🇺🇸

Elkhart, Indiana, United States

Fort Wayne Medical Oncology and Hematology Inc-Parkview

🇺🇸

Fort Wayne, Indiana, United States

Saint John Macomb-Oakland Hospital

🇺🇸

Warren, Michigan, United States

Proctor Hospital

🇺🇸

Peoria, Illinois, United States

Alta Bates Summit Medical Center - Summit Campus

🇺🇸

Oakland, California, United States

Armstrong Center for Medicine and Health

🇺🇸

Kittanning, Pennsylvania, United States

The James Graham Brown Cancer Center at University of Louisville

🇺🇸

Louisville, Kentucky, United States

Roper Hospital

🇺🇸

Charleston, South Carolina, United States

University of Hawaii

🇺🇸

Honolulu, Hawaii, United States

Kapiolani Medical Center for Women and Children

🇺🇸

Honolulu, Hawaii, United States

The Cancer Center of Hawaii-Liliha

🇺🇸

Honolulu, Hawaii, United States

Tripler Army Medical Center

🇺🇸

Honolulu, Hawaii, United States

Iowa Oncology Research Association CCOP

🇺🇸

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Des Moines

🇺🇸

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates-Laurel

🇺🇸

Des Moines, Iowa, United States

Albert Einstein College of Medicine

🇺🇸

Bronx, New York, United States

Wichita CCOP

🇺🇸

Wichita, Kansas, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

University of Rochester

🇺🇸

Rochester, New York, United States

Miami Valley Hospital

🇺🇸

Dayton, Ohio, United States

Bay Area Tumor Institute CCOP

🇺🇸

Oakland, California, United States

Tom K Lee Inc

🇺🇸

Oakland, California, United States

Kaiser Permanente-Oakland

🇺🇸

Oakland, California, United States

Minnesota Oncology Hematology PA-Maplewood

🇺🇸

Maplewood, Minnesota, United States

Cancer Center of Kansas - El Dorado

🇺🇸

El Dorado, Kansas, United States

McKee Medical Center

🇺🇸

Loveland, Colorado, United States

Sky Ridge Medical Center

🇺🇸

Lone Tree, Colorado, United States

Cone Health Alamance Regional Medical Center

🇺🇸

Burlington, North Carolina, United States

Southern Regional Medical Center

🇺🇸

Riverdale, Georgia, United States

Montefiore Medical Center

🇺🇸

Bronx, New York, United States

University of Kansas Medical Center

🇺🇸

Kansas City, Kansas, United States

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