Determinants of Post-Exercise Eating Patterns

Not Applicable

• Conditions: Obesity
• Interventions: Behavioral: Exercise and Meal (EX); Behavioral: No-Exercise and Meal (NEX)

• Registration Number: NCT03643315
• Lead Sponsor: Clinical Nutrition Research Centre, Singapore

Brief Summary

This study examines potential physiological and psychological determinants of food intake in response to exercise. Specifically, beyond measuring actual food consumption and physiological markers typically assessed during exercise and appetite work (i.e. appetite hormones, blood glucose), the investigators wish to investigate the influence of individual behavioural differences (attitudes towards eating, licensing/compensatory health beliefs, self-regulation, and exercise-associated motivation) on the relationship between exercise and eating behaviour.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-08-07
• Study First Submitted QC: 2018-08-21
• Study First Posted: 2018-08-22
• Study Start: 2018-09-27
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-23
• Last Update Posted: 2019-07-25
• Primary Completion: 2019-09
• Study Completion: 2019-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Male
• Inactive (< 90 min of moderate-intensity exercise a week)
• BMI: 23 and above
• Age between 21 to 40 years
• Normal fasting blood glucose levels equal to or less than 5.9 mmol/L
• Non-smoker
• No know allergies or intolerance to food
• Not on any prescribed medication
• No physical disabilities and/or restrictions; not averse to exercising on a stationary bike or treadmill running
• No aversion to blood sampling procedures (e.g. finger prick, cannulation)

Exclusion Criteria

• Female,

• Smoker,

• Fasting blood glucose > 5.9 mmol/L,

• Resting blood pressure > 140/90 mmHg,

• Any major medical/health conditions including

  • Diabetes,
  • Metabolic disease
  • Hypertension,
  • Cardiovascular disease,
  • Thyroid disorders,
  • G6PD deficiency.

• Allergic or intolerant to foods presented in the study.

• Physical disabilities and/or restrictions.

• Individuals that are adverse to exercising on a stationary exercise bike or treadmill.

• Adverse to blood sampling procedures (i.e. cannulation, finger pricks, venepuncture).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Exercise and Meal (EX)	Exercise and Meal (EX)	The EX protocol will involve a 30 minute acute bout of high intensity intermittent exercise on a stationary exercise bike followed by an ad-libitum test meal.
No-Exercise and Meal (NEX)	No-Exercise and Meal (NEX)	The NEX protocol will involve a 30 minute period of rest (to match the exercise period in EX) where participants will be provided a video/movie. Following this, participants will be provided ad-libitum access to a test meal (as per EX energy intake assessment protocol)

Primary Outcome Measures

Name	Time	Method
Ad-libitum amount of food consumed in response to experimental condition: exercise or rest (no exercise).	3 hours	Participants' eating behaviour will be assessed by measuring the total amount of the test meal consumed in each experimental condition. The test meal will be provided ad-libitum (i.e. there will be non-restricted access)

Secondary Outcome Measures

Name	Time	Method
Subjective ratings of desire to eat in response to experimental conditions	3 hours	Self-reported subjective ratings of desire to eat will be assessed periodically through the experimental session. Assessed via 100-point visual analogue scales
Subjective ratings of satiation (fullness) in response to experimental conditions	3 hours	Self-reported subjective ratings of satiation (fullness) will be assessed periodically through the experimental session. Assessed via 100-point visual analogue scales
Appetite-related blood hormone concentration in response to experimental conditions.	3 hours	Venous blood will be sampled for the measurement of a range of appetite-related hormones including Active Ghrelin (pg/ml), Glucagon-like Peptide-1 (GLP-1) (pg/ml), Pancreatic YY (PYY) (pg/ml), Pancreatic Polypeptide (PP) (pg/ml), periodically through the experimental sessions.
Subjective ratings of hunger in response to experimental conditions	3 hours	Self-reported subjective ratings of hunger will be assessed periodically through the experimental session. Assessed via 100-point visual analogue scales.
Subjective ratings of prospective food consumption in response to experimental conditions	3 hours	Self-reported subjective ratings of prospective food consumption will be assessed periodically through the experimental session. Assessed via 100-point visual analogue scales.
Metabolic blood variable concentration in response to experimental conditions	3 hours	Venous blood will be sampled for the measurement of metabolic blood variables blood insulin (mmol/L) and blood glucose (mmol/L) periodically through the experimental sessions.
Free-living energy intake (1 day post-experiment) in response to experimental conditions	1 day	1 day free-living energy intake (self-report)
Free-living physical activity levels intake (1 day post-experiment) in response to experimental conditions	1 day	1 day free-living physical activity levels (physical activity monitors)

Trial Locations

Locations (1)

Clinical Nutrition Research Centre; 🇸🇬 Singapore, Singapore