Quadratus Lumborum Block for Postoperative Analgesia After Colostomy Closure

Phase 4

• Conditions: Postoperative Pain
• Interventions: Drug: normal saline; Drug: levo-bupivacaine

• Registration Number: NCT02691403
• Lead Sponsor: Sun Yat-sen University

Brief Summary

Patients undergoing abdominal procedures often require multimodal postoperative pain controls. Truncal blocks such as quadratus lumborum (QL) block may be used adjunctively as a part of it. The investigators hypothesized that the ultrasound-guided QL block with transmuscular approach can provide adequate pain relief for colostomy closure as part of a multimodal pain control.

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-02
• Study First Submitted: 2016-02-17
• Study First Submitted QC: 2016-02-21
• Last Update Submitted: 2016-02-21
• Study First Posted: 2016-02-25
• Last Update Posted: 2016-02-25
• Study Start: 2016-03
• Primary Completion: 2017-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• A physical status between ASA I and III
• 20 - 75 years of age
• Patient has signed an informed consent
• Without contraindication of QL block

Exclusion Criteria

• American Society of Anesthesiologists (ASA) Physical Status ≥ 4
• Any contraindication to nerve blocks (including coagulopathy, abnormal anatomy, infection at the planned QL injection site, and amide-type local anesthetic allergy) pregnancy or breast-feeding
• Severe obesity (body mass index≥ 35 kg/m2)
• Patients with a history of significant neurological, psychiatric, neuromuscular, cardiovascular, pulmonary, renal or hepatic disease
• Allergy to NSAIDs
• Infection at the QL injection site
• Patients with major psychosis or drug and alcohol abuse
• Patient unable to comprehend or use the verbal rating pain scoring system or patient-controlled analgesia pump

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo QL block	normal saline	30 ml single shot QL block with saline 0.9%
Active QL block	levo-bupivacaine	30 ml single shot QL block with 0.25% levo-bupivacaine

Primary Outcome Measures

Name	Time	Method
cumulative morphine consumption	1 hour