Efficacy of Repetitive Transcranial Magnetic Stimulation in Treating Refractory Obsessive Compulsive Disorder

Not Applicable

• Conditions: refractory obsessive compulsive disorder.; Mixed obsessional thoughts and acts

• Registration Number: IRCT201308041743N11
• Lead Sponsor: Research center for behavioral disorders and substance abuse, Hamadan University of Medical Science

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Inclusion Criteria:

•voluntary and competent to consent based on their ability to provide a spontaneous narrative description of the key elements of the study
•have a Structured Clinical Interview for DSM-IV (SCID) confirmed diagnosis of OCD
•are between the ages of 18 and 65
•have failed to achieve a clinical response, or did not tolerate, at least 3 separate antidepressant trials of sufficient dose (included clomipramine) and CBT for at least 10 weeks
•have a score of greater than or equal to 17 on the Y-BOCS. A careful medical and neurological history will be taken to ensure that subjects have no unstable conditions that would preclude them from entering into the study. This history will focus on conditions such as seizures, neurologic, other medical problems and presence of metal implants

Exclusion Criteria

•have a history of DSM-IV substance dependence in the last 6 months, and have DSM-IV substance abuse in the last month
•have a concomitant major unstable medical or neurologic illness or have had a history of seizures
•acutely suicidal
•are pregnant
•have metal implants. With respect to concomitant medications, patients will be excluded if they are currently (or in the last 4 weeks) taking: (a) more than lorazepam 2 mg daily (or equivalent), (b) monoamine oxidase inhibitors, (c) and/or bupropion due to its associated increased risk for seizures.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement rate of refractory OCD. Timepoint: after 10th, 20th sessions of rTMS or sham. Method of measurement: CGI ? YBOCS.