Hypothermia induced changes in organ perfusion in patients after cardiac arrest

Recruiting

Conditions: bloedruk en orgaandoorbloeding na hartstilstand
cardiac arrest
organ blood flow
10029305

Registration Number: NL-OMON35322

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

- Informed consent
- Age >= 18 years
- Out of hospital cardiac arrest
- Initial rhythm on arrival of the ambulance ventricular fibrillation or non-perfusion ventricular tachycardia or a presumed cardiac origin of the arrest
- Glasgow coma score upon arrival at the hospital of 8 or less
- Indication for mild therapeutic hypothermia

Exclusion Criteria

- Comatose state before cardiac arrest or known neurological disease
- Cardiogenic shock, defined as mean arterial pressure less than 60 mmHg and/or urine production < 0.5 ml/kg bodyweight/hour, despite use of inotropic agents
- Hypoxemia, defined as oxygen saturation in arterial blood < 85%
- Chronic renal failure (creatinine > 200 µmol/ml), chronic liver failure
- Pregnancy

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study endpoint is the change in blood viscosity in time during hypothermia<br /><br>and subsequent rewarming.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are<br /><br>- Hemodynamic changes, such as heart rate, blood pressure, cardiac output,<br /><br>central venous pressure, pulse pressure variation (PPV), stroke volume, stroke<br /><br>volume variation (SVV), systemic vascular resistance (SVR), global<br /><br>end-diastolic volume, intrathoracic blood volume, and extravascular lung water<br /><br>during hypothermia and rewarming.<br /><br>- Changes in parameters of cardiac compliance during hypothermia and rewarming.<br /><br>- Changes in cerebral, renal and splanchnic blood flow during hypothermia and<br /><br>rewarming.<br /><br>- Changes in cerebral autoregulation during hypothermia and rewarming.<br /><br>- Effect of fluid resuscitation on hemodynamic parameters and whole blood<br /><br>viscosity during hypothermia and rewarming.</p><br>