Effects of Induced Hypothermia on Respiratory parameters and Immunological functio

Completed

• Conditions: Hypothermia; Artificial induced low body temperature; 10005908; 10027665; 10038716

• Registration Number: NL-OMON34602
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

For the observational part of the study:
- Admission to the ICU after cardio pulmonary resuscitation
- Treatment with induced mild hypothermia according to protocol, as part of standard patient care
For the case-control part of the study, 2 additional groups will be included:
- Mechanically ventilated normothermic, non-infectious patients
- Healthy volunteers

Exclusion Criteria

Exclusion cirteria are:
- No informed consent
- Inability to complete 24 hours of hypothermia
- Presence of pulmonary fibrosis

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main endpoint of this study is P/F ratio as a measure of oxygenation and<br /><br>end tidal CO2 as a measure of ventilation. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Respiratory:<br /><br>oxygenation index, lung injury score, static compliance, dead space<br /><br>ventilation, oxygen consumption.<br /><br><br /><br>Immunological:<br /><br>levels of pro-inflammatory chemokines and cytokines (TNF-alpha, Il-1beta, and<br /><br>IL-6, IL-2, IFN-g, IL-8), whole blood stimulation, HLA-DR expression. </p><br>