Effect of mild therapeutic hypothermia in post cardiac arrest patients on inflammatory response
Completed
- Conditions
- brain damagecardiac arrest10019280
- Registration Number
- NL-OMON39281
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 51
Inclusion Criteria
- age >=18 years
- post cardiac arrest with spontaneous return of circulation
- undergoing mild therapeutic hypothermia
- admittance to the intensive care
- written informed/deferred consent
Exclusion Criteria
-pregnancy
-severe traumatic brain injury
-cardiac arrest due to submersion
-infection already present before collapse
-moribund patients
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Determine whether minor variations in the expression of systemic pro- and<br /><br>anti-inflammatory markers in post-CA patients during treatment with hypothermia<br /><br>result in better neurological outcome compared to patients showing large<br /><br>variations. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Does the expression of pro- and anti-inflammatory markers relate to<br /><br>mechanical ventilation days, length of stay at the ICU and survival of the<br /><br>patients?<br /><br>- Is there an association between the expression of pro- and anti-inflammatory<br /><br>markers and speed of cooling and re-warming?<br /><br>- Is there an association between the expression of pro- and anti-inflammatory<br /><br>markers and temperature stability during the maintenance phase of MTH?<br /><br>- Is there a relation between hypoperfusion (measured with NIRS) and markers of<br /><br>inflammation before, during and after induction of MTH in post-CA patients</p><br>