Influence of Preprandial Metformin Administration on Carbohydrate Absorption

Not Applicable

Not yet recruiting

• Conditions: Type2 Diabetes; Impaired Glucose Tolerance
• Interventions: Other: Oral glucose tolerance test (OGTT) with or without metformin

• Registration Number: NCT04018105
• Lead Sponsor: University Hospital, Lille

Brief Summary

Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.

It is usually recommended to take metformin during the meal to decrease gastrointestinal side effects. However, if metformin decreases carbohydrate absorption, this might not be the most efficient intake.

To study the influence of preprandial metformin administration on carbohydrate absorption, it will repeat 3 oral glucose tolerance test on obese dysglycemic patients, without metformin or with metformin administer 30 or 60 minutes before. We will also evaluate how it impacts gastrointestinal tolerance.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-07-10
• Study First Submitted QC: 2019-07-10
• Study First Posted: 2019-07-12
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-18
• Last Update Posted: 2022-08-19
• Study Start: 2022-12
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 24

Inclusion Criteria

• Obesity (BMI ≥30 kg/m2)
• Dysglycemia (HbA1c≥ 6,0 %)
• No anti diabetic medication

Exclusion Criteria

• No obesity (BMI < 30 kg/m2)
• No dysglycemia (HbA1c <6,0%)
• Treatment that might interfere with carbohydrate absorption (anti diabetic medication, antibiotics, probiotics, steroids)
• Anemia (Hb <12 g/dL)
• Organ failure
• Inflammatory Bowel Disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
taking metformin 30 or 60 minutes before the OGTT	Oral glucose tolerance test (OGTT) with or without metformin	-
No metformin before OGTT	Oral glucose tolerance test (OGTT) with or without metformin	-

Primary Outcome Measures

Name	Time	Method
Area under the curve of D-Xylose	During the 3 hours OGTT

Secondary Outcome Measures

Name	Time	Method
Area under the curve of blood glucose	During the 3 hours OGTT
Number of Participants with gastrointestinal side effects	During the 3 hours OGTT
Area under the curve of insulin	During the 3 hours OGTT
Area under the curve of GLP-1	During the 3 hours OGTT