Comparison of effect of High Intensity Exercise with Aerobic exercise on Nerve conduction velocity in Prediabetes

Completed

• Conditions: Prediabetes

• Registration Number: CTRI/2012/09/002975
• Lead Sponsor: Government Medical College Aurangabad

Brief Summary

The present study is being carried out to compare the effects of traditional aerobic training and Sprint Interval Training on Nerve Conduction velocity and Audiovisual reaction time in subjects of Prediabetes.

44 patients of Prediabetes will be enrolled for the study. Diagnosis of prediabetes will be according to American Diabetes Association (ADA) guidelines.

By computer generated Randomization and proper allocation concealment and blinding, the study subjects will be allocated to aerobic training and sprint interval training groups.

Following parameters will be measured at the beginning of study and after 6 weeks.

Primary outcome: NCV,

Secondary outcome: Audiovisual Reaction time

Statistical analysis will be done to compare the effect of both interventions.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2012-10-16
• Study Start: 2012-11-09

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 44

Inclusion Criteria

• 1. Prediabetes: Impaired fasting glucose (IFG).
• FPG 100-125 mg/dl OR Impaired glucose tolerance((IGT)- 2hr PPG 140-199mg/dl 2) Age group: 25 to 40 years. 3) Asymptomatic males with a normal baseline ECG.

Exclusion Criteria

• 1.Resting blood pressure greater than or equal to 160/100 mm Hg 2.
• Triglycerides greater than or equal to 500 mg/dL 3.
• Factors that may limit adherence to intervention or affect conduct of the trial such as lack of time, amount of travel, and/or work or family stressors 4.
• Unable or willing to communicate with staff, to provide written informed consent, or accept the randomized assignment 5.
• Failure to complete behavioral run-in and baseline testing 6.
• Not physically capable of performing the exercise required of the study protocols 7.
• Plans to be away >4 weeks in the next 6 months 8.
• Lack of support from primary health care provider or family members 9.
• Significant weight loss in the past year (>20 kg) or current use of weight loss medications 10.
• Current diagnosis of schizophrenia, or other psychotic disorders, or bipolar disorder 11.
• History of bariatric surgery within last 3 years 12.
• Other medical, psychiatric, or behavioral limitations that in the view of the principal investigator may interfere with study participation or the ability to follow the intervention protocol 14.
• Underlying diseases or conditions likely to limit lifespan and/or affect the safety of the intervention 15.
• Self-report HIV or tuberculosis 16.
• History or evidence of serious arrhythmias, cardiomyopathy, congestive heart failure, aortic aneurysm, or heart transplantation 17.
• Renal disease: currently receiving dialysis 18.
• Type I diabetes mellitus 19.
• Any other medical condition or disease that is life threatening or that can interfere with or be aggravated by exercise 21.
• Chronic obstructive lung disease, peripheral vascular disease or angina that limits ability to follow exercise protocol 22.
• Advanced neuropathy or retinopathy 23.
• Consuming alcoholic beverages, Smoker or have used nicotine/tobacco products within the last 12 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Nerve Conduction Velocity	6 weeks

Secondary Outcome Measures

Name	Time	Method
Audiovisual reaction time	6 weeks

Trial Locations

Locations (1)

Government Medical College, Aurangabad; 🇮🇳 Aurangabad, MAHARASHTRA, India

Government Medical College, Aurangabad

🇮🇳Aurangabad, MAHARASHTRA, India

Dr Khaled Mohsin Badaam

Principal investigator

02402402412

khalid_badaam@yahoo.com