Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

Phase 2

Completed

• Conditions: Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory
• Interventions: Other: aerobic exercise training

• Registration Number: NCT01515033
• Lead Sponsor: Hospital TotalCor

Brief Summary

The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.

Detailed Description

End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. In this regard, it has been shown that patients with cardiac disease have an abnormally low PETCO2 during exercise, especially those with an impaired response of cardiac output during exercise

Study Timeline

• Study Start: 2010-09
• Primary Completion: 2011-06
• Study Completion: 2011-08
• Status Verified: 2012-01
• Study First Submitted: 2012-01-18
• Study First Submitted QC: 2012-01-20
• Last Update Submitted: 2012-01-20
• Study First Posted: 2012-01-23
• Last Update Posted: 2012-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Continuous exercise training	aerobic exercise training	The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
interval exercise training	aerobic exercise training	The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Primary Outcome Measures

Name	Time	Method
PetCO2 response during graded exercise test	before and after 3 months of the interventions	End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation