Determination of complement binding HLA-C antibodies with single-antigen-expressing cell lines (SAL) in pregnancies complicated by preeclampsia
Completed
- Conditions
- Pregnancy toxicosis10026908
- Registration Number
- NL-OMON38539
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 132
Inclusion Criteria
We select primiparous women with an uncomplicated, term pregnancy (control) and preeclampsia (case) who deliver at the Leiden University Medical Center. Preeclampsia is defined as gestational hypertension (systolic pressure >= 140 mmHg and/or diastolic pressure >= 90 mmHg detected after 20th week of gestation) or worsening of preexistent hypertension and proteinuria (>= 0.3 gr/l/24hours).
Exclusion Criteria
Maternal autoimmune diseases as antiphospholipid syndrome or SLE, drugs, use of immunosuppressive medication, intrauterine infections and bloodtransfusions or organ transplantions in medical history.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method