BNP Measurement Reduces Resource Utilization for Patients With CHF Admitted Thorough the ED

Completed

• Conditions: Congestive Heart Failure

• Registration Number: NCT00587938
• Lead Sponsor: Mayo Clinic

Brief Summary

Measurement of brain natriuretic peptide (BNP) in dyspneic patients increases diagnostic accuracy for congestive heart failure (CHF). Limited information is available regarding economic outcomes attributable to BNP assay. The aim of this study was to assess the economic impact of BNP assay in elderly dyspneic patients presenting to the emergency department (ED).

Detailed Description

Dyspneic patients 65 years were enrolled in a randomized, controlled trial; hemodynamically unstable patients were excluded. BNP (Biosite assay) levels were measured prior to physician assessment with randomization in 1:1 ratio to either BNP 1) level reported or 2) level not reported. ED physicians made triage decisions guided by clinical judgment and nomogram to aid in interpretation of BNP level. Primary outcome was mean total hospital cost per subject. Secondary outcomes included admission rate, service assignment, discharge diagnosis and length of stay. Differences between groups were compared by t-test with bootstrap. Costs reflect 2005 constant dollars.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2003-12
• Primary Completion: 2005-03
• Study Completion: 2005-03
• Status Verified: 2007-12
• Study First Submitted: 2007-12-26
• Study First Submitted QC: 2007-12-26
• Last Update Submitted: 2007-12-26
• Study First Posted: 2008-01-08
• Last Update Posted: 2008-01-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Dyspneic patients 65 years or older presenting to the ED with chief complaint of shortness of breath.

Read More

Exclusion Criteria

• hemodynamically unstability

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean total hospital cost per subject	spans from ED eval through hospitalization discharge

Secondary Outcome Measures

Name	Time	Method
Included admission rate, service assignment, discharge diagnosis, and length of stay.	from ED evaluation through hospitalization discharge

Trial Locations

Locations (1)

Saint Marys Hospital, Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States