Dopamine in Orthostatic Tolerance
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- plasma dopamine-beta-hydroxylase
研究概览
简要总结
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate. We will also study whether increasing dietary salt improves symptoms during upright posture. Finally, we will examine whether the dietary sodium level influences serum DBH activity and whether DBH level influences the response to sodium. DBH levels and the function of the sympathetic or involuntary nervous system will be assessed in normal volunteers and in patients with postural tachycardia syndrome (POTS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Upright plasma norepinephrine > 600 pg/ml, or
- •An increase in heart rate of > 30 beats per minute upon standing, and
- •Withdrawal of all medications for at least 3 days, and
- •No associated medical illness, and
- •Age 18 - 60 years old.
排除标准
- •Older than 60 years of age
- •Routinely taking medications affecting the autonomic nervous system
- •Any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic) other than POTS
- •Anemia (Hct < 30)
- •Women of childbearing age who are pregnant or nursing
- •Unable to give informed consent
结局指标
主要结局
plasma dopamine-beta-hydroxylase
时间窗: at enrollment and after tests
plasma dopamine
时间窗: after tests
次要结局
未报告次要终点
研究者
Emily M. Garland
Research Assistant Professor
Vanderbilt University