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临床试验/NCT02248987
NCT02248987已完成不适用

Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia

Seoul National University Hospital1 个研究点 分布在 1 个国家目标入组 36 人开始时间: 2014年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
36
试验地点
1
主要终点
Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.

研究概览

简要总结

The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
20 Years 至 55 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • diagnosis of schizophrenia
  • clinically stable state

排除标准

  • history of previous head injury, epileptic disorder, other medical comorbidity
  • substance abuse/dependence

结局指标

主要结局

Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.

时间窗: within 2 weeks from enrollment

次要结局

  • resting state functional magnetic resonance imaging(within 2 weeks from enrollment)
  • neurocognitive function test(within 2 weeks from enrollment)
  • clinical measure including Positive and Negative Syndrome Scale(within 2 weeks from enrollment)
  • diffusion tensor imaging(within 2 weeks from enrollment)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jun Soo Kwon

professor

Seoul National University Hospital

研究点 (1)

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