NCT02248987CompletedNot Applicable
Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia
Seoul National University Hospital1 site in 1 country36 target enrollmentStarted: May 2014Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.
Study Overview
Brief Summary
The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 20 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •diagnosis of schizophrenia
- •clinically stable state
Exclusion Criteria
- •history of previous head injury, epileptic disorder, other medical comorbidity
- •substance abuse/dependence
Outcomes
Primary Outcomes
Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.
Time Frame: within 2 weeks from enrollment
Secondary Outcomes
- resting state functional magnetic resonance imaging(within 2 weeks from enrollment)
- neurocognitive function test(within 2 weeks from enrollment)
- clinical measure including Positive and Negative Syndrome Scale(within 2 weeks from enrollment)
- diffusion tensor imaging(within 2 weeks from enrollment)
Investigators
Jun Soo Kwon
professor
Seoul National University Hospital
Study Sites (1)
Loading locations...
Similar Trials
Completed
Not Applicable
Investigating dopamine synthesis capacity in (pathological) gamblers: An explorative Positron Emission Tomography studygambling addictionpathological gambling10021563NL-OMON37017Radboud Universiteit Nijmegen48
Unknown
Not Applicable
[18 Fluorine(F)]DOPA Determinants and Predictors of Treatment Response in PsychosisSchizophreniaNCT02880995Seoul National University Hospital62
Completed
Not Applicable
How the Loss of Dopamine and Dopamine-Restoring Medicines Affect Movement PerformanceParkinson DiseaseNCT00040196National Institute of Neurological Disorders and Stroke (NINDS)133
Completed
Not Applicable
Reproducibility of dopamine synthesis capacity measured with [11C]DOPA and dopamine transporter binding measured with [18F]FE-PE2I using positron emission tomographyHealthy male adultsJPRN-UMIN000005255Molecular Imaging Center, National Institute of Radiological Sciences20
Completed
Not Applicable
Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.Attention DisturbancesParkinson DiseaseNCT03476668Ospedale Generale Di Zona Moriggia-Pelascini100