Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia

Completed

• Conditions: Schizophrenia
• Interventions: Other: patients treated with antipsychotics

• Registration Number: NCT02248987
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2014-09-22
• Study First Submitted QC: 2014-09-22
• Study First Posted: 2014-09-25
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-04
• Last Update Posted: 2019-04-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• diagnosis of schizophrenia
• clinically stable state

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Exclusion Criteria

• history of previous head injury, epileptic disorder, other medical comorbidity
• substance abuse/dependence

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Clozapine	patients treated with antipsychotics	stable patients treated with clozapine
Other antipsychotics	patients treated with antipsychotics	stable patients treated with risperidone or paliperidone or olanzapine
Healthy volunteer	patients treated with antipsychotics	healthy controls

Primary Outcome Measures

Name	Time	Method
Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging.	within 2 weeks from enrollment

Secondary Outcome Measures

Name	Time	Method
resting state functional magnetic resonance imaging	within 2 weeks from enrollment
neurocognitive function test	within 2 weeks from enrollment
clinical measure including Positive and Negative Syndrome Scale	within 2 weeks from enrollment
diffusion tensor imaging	within 2 weeks from enrollment

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of