Study on Abnormal Dopamine Synthesis and Connectivity According to the Antipsychotic Treatment Response in Schizophrenia
Completed
- Conditions
- Schizophrenia
- Registration Number
- NCT02248987
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to evaluate abnormal dopamine synthesis and connectivity according to the antipsychotic treatment response in schizophrenia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- diagnosis of schizophrenia
- clinically stable state
Exclusion Criteria
- history of previous head injury, epileptic disorder, other medical comorbidity
- substance abuse/dependence
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Striatal [18F]-DOPA uptake measured using positron emission tomographic 18F-dopa imaging. within 2 weeks from enrollment
- Secondary Outcome Measures
Name Time Method resting state functional magnetic resonance imaging within 2 weeks from enrollment neurocognitive function test within 2 weeks from enrollment clinical measure including Positive and Negative Syndrome Scale within 2 weeks from enrollment diffusion tensor imaging within 2 weeks from enrollment
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of