Relationship Between Dopaminergic Asymmetric Degeneration and Attentional Resources in Parkinson's Disease.

Not Applicable

Completed

• Conditions: Parkinson Disease; Attention Disturbances

• Registration Number: NCT03476668
• Lead Sponsor: Ospedale Generale Di Zona Moriggia-Pelascini

Brief Summary

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).

Detailed Description

To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.

The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.

Study Timeline

• Study Start: 2017-01-01
• Primary Completion: 2017-08-01
• Study Completion: 2017-08-01
• Study First Submitted: 2018-03-19
• Study First Submitted QC: 2018-03-19
• Study First Posted: 2018-03-26
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-28
• Last Update Posted: 2018-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);
• Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;
• Mini Mental State Examination (MMSE) ≥ 24;
• No evidences of dysexecutive syndrome.

Exclusion Criteria

• Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;
• Drug-induced dyskinesias;
• Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;
• Behavioral disturbances (evaluated with Neuropsychiatric Inventory);
• Visual and auditory dysfunctions according to the general clinical evaluation and medical history;
• Equivocal report about the side of disease onset or bilateral motor involvement.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Multiple Choices RTs (MC RTs)	4 weeks	Multiple Choices RTs
Auditory Reaction Times (A RTs)	4 weeks	Auditory Reaction Times
Visual Reaction Times (V RTs)	4 weeks	Visual Reaction Times

Secondary Outcome Measures

Name	Time	Method
Unified Parkinson's Disease Rating Scale (UPDRS)	4 weeks	Unified Parkinson's Disease Rating Scale
Timed Up and Go Test (TUG)	4 weeks	Timed Up and Go Test