Right Ventricular Dysfunction in Septic Shock Patients in ICU

Not yet recruiting

• Conditions: Septic Shock

• Registration Number: NCT05193682
• Lead Sponsor: Shimaa Hammad Ahmed

Brief Summary

Assesment of right ventricular dysfunction in septic shock patients in intensive care unit.

Detailed Description

Over the last decade, a few studies have highlighted the crucial role of right ventricular (RV) function in hemodynamic and respiratory diseases in critical care 1,2. However, RV failure is difficult to define in the critical care setting. A recent consensual definition proposed by different groups of experts characterizes RV failure as the association of a significant RV dilatation associated with systemic congestion 3-5. This definition is mainly physiologically based, not strictly validated, and the experts did not propose any threshold for RV size or congestion using critical care echocardiography (CCE) and central venous pressure (CVP), respectively.

Fluid management in septic shock is crucial for prognosis, as fluid overload and high CVP are associated with a worse outcome 6. Septic shock is expected to impair RV function through the development of septic cardiomyopathy, but the incidence of RV failure is unknown.

Study Timeline

• Study First Submitted: 2021-12-30
• Study First Submitted QC: 2022-01-03
• Study First Posted: 2022-01-18
• Status Verified: 2022-10
• Study Start: 2022-10
• Last Update Submitted: 2022-10-24
• Last Update Posted: 2022-10-25
• Primary Completion: 2023-03
• Study Completion: 2023-03

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Patients diagnosed with septic shock.
2. Patients will be evaluated within 24 h after diagnosis.

Exclusion Criteria

1. Patients diagnosed more than 24 hours.
2. Patients with associated ischemic heart failure .

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Right ventricular dysfunction in septic shock patients in intensive care unit	3 years	Fluid management in septic shock is crucial for prognosis, as fluid overload and high CVP are associated with a worse outcome 6. Septic shock is expected to impair RV function through the development of septic cardiomyopathy, but the incidence of RV failure is unknown.