RBR-10jpb6v7
Recruiting
Not Applicable
Adult Acute Lymphoblastic Leukemia treated with pediatric regimen – a prospective observational study
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo0 sitesSeptember 13, 2023
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute lymphoblastic leukemia
- Sponsor
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients between 16 and 50 years\-old; both genders; with newly diagnosed Acute Lymphoblastic Leukemia \- ALL; negative for Philadelphia chromosome; not previously treated (except for hydroxyurea, corticosteroids, or intrathecal chemotherapy) with at least 20% blasts in peripheral blood and/or bone marrow
Exclusion Criteria
- •Burkitt leukemia. Prior chronic myeloproliferative disease. Philadelphia chromosome positivity. ECOG\>2\. Total bilirubin\>2x upper limit of normality. Transaminases\>5x ULN. Creatinine\>2,5 mg/dl. Positive serology for HIV or HTLV. Heart failure NYHA Class III or IV. Severe psychiatric disorder which prevents adequate compliance. Prior treatment with intravenous chemotherapy, except for hydroxyurea and corticosteroids. Refusal to participate in the study. Down syndrome
Outcomes
Primary Outcomes
Not specified
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