ACTRN12621001016820
Recruiting
未知
A randomised trial of the effect of prophylactic fluid restriction on the incidence of delayed hyponatraemia following pituitary surgery in adults
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diabetes insipidus
- Sponsor
- Princess Alexandra hospital
- Enrollment
- 80
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Undergoing pituitary surgery
- •2\.Pituitary tumour (functional and non\-functional pituitary adenomas, Rathke’s cleft cyst, craniopharyngioma, other)
- •3\.Adults 18 years of age or older
- •4\.Willingness and able to give written or oral informed consent and willingness to participate to and comply with the study.
Exclusion Criteria
- •Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study, as pregnancy may interfere with the results of the study, and this group would make up an extremely small number of patients undergoing pituitary surgery.
- •Participants with a history of a psychological illness or condition such as to interfere with the participant’s ability to understand the requirements of the study.
- •Participants with diabetes mellitus and significant hyperglycaemia postoperatively (blood glucose levels greater than 12 mmol/L) or who have other causes of osmotic diuresis.
- •The following medication(s) can have interactive effects and may interfere with the participants ability to meet the study requirements; they cannot be administered during the clinical study:
- •oDiuretic medications, mannitol, medications known to affect plasma sodium (including SSRIs, TCAs, anti\-epileptics medications)
- •Any patient with a pre\-existing diagnosis of DI, or those requiring DDAVP on discharge (usually around day 4 post\-op), or other medical condition where fluid restriction would be considered dangerous.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Amsterdam Lifestyle Intervention on Food and Exercise at WorkOverweightNutritional, Metabolic, EndocrineObesityISRCTN04265725Vrije University Medical Centre (VUMC) (The Netherlands)1,386
Completed
Not Applicable
Prophylactic Antibiotics for the Treatment of Cellulitis at Home IRecurrent cellulitis of the legSkin and Connective Tissue DiseasesCellulitisISRCTN34716921niversity of Nottingham (UK)260
Not yet recruiting
Not Applicable
A randomised controlled trial of faecal microbiota transplantation versus placebo in patients who are non -responders to the low FODMAP diet.ACTRN12623000353695Vincent Ho40
Completed
Not Applicable
A randomized controlled trial of preventative effect on wound complication after gastrointestinal surgery by coated antibacterial suturegastrointestinal neoplasmJPRN-UMIN000002550Osaka Medical Center for Cancer and Cardiovascular Diseases75
Completed
Not Applicable
A randomised controlled trial of the effects of fruit intake on cardiovascular disease risk factors in childreCardiovascular disease risk factors in childrenDiet and Nutrition - ObesityCardiovascular - Coronary heart diseasePublic Health - Health promotion/educationACTRN12613001280796Monash University250