Predective Factors for Tumor Aggressiveness in Medullary Thyroid Cancer
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 500
- Locations
- 46
- Primary Endpoint
- Central lymph node metastasis
Study Overview
Brief Summary
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival.
Detailed Description
This study is a retrospective study trying to find the predictive factors for medullary thyroid aggressiveness in terms of tumor metastasis and patients' survival. The predictive factors included in this study are central and lateral compartment lymph node metastases as well as distant metastasis up to 1 year postoperatively, while biochemical predictors (meaning ratios such as lymphocyte to monocyte ratio etc and CEA and calcitonin drop levels) and histological predictors (such as nuclear atypia, amyloid, immunohistochemistry, desmoplasia) are included as secondary outcomes. In this study , patients >18 years old that underwent surgery for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection) will be enrolled.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy, completion thyroidectomy) +/- central/lateral neck dissection
Exclusion Criteria
- •Age < 18 years
Outcomes
Primary Outcomes
Central lymph node metastasis
Time Frame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Central neck compartment lymph node metastasis
Lateral lymph node metastasis
Time Frame: Number of lymph node Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Lateral neck compartment lymph node metastasis
Distant metastasis
Time Frame: Number of distant Metastasis found in preoperative imaging studies or up to 1 year postoperatively
Liver and lung metastasis
Secondary Outcomes
- Nuclear atypia as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- White blood cell as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- Amyloid as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- CEA as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- Immunohistochemistry as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- Calcitonin as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
- CEA drop as Biochemical cure marker(up to 1 year postoperatively)
- Calcitonin drop as Biochemical cure marker(up to 1 year postoperatively)
- Desmoplasia as histological predictor of aggressiveness(The pathology report is held immediately after surgery)
- Platelet count as Biochemical predictor of aggressiveness(pre and postoperative laboratory exams up to 1 year postoperatively)
Investigators
Papavramidis Theodossis
Associate Professor
Aristotle University Of Thessaloniki