Interaction of Statins and Nondepolarizing Muscle Relaxants
- Conditions
- Pain
- Interventions
- Registration Number
- NCT02222519
- Lead Sponsor
- Huang-wei LV
- Brief Summary
provide evidence for prevention or reduction muscle pain.
- Detailed Description
The purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,In order to provide evidence for prevention or reduction muscle pain.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Patients with American Society of Anesthesiologists physical status I-III
- Patients taking statins for at least 3 months and those who had never used statins were considered to be eligible
Exclusion Criteria
- Orthopedic
- Spinal surgery
- Surgery involving extensive muscle manipulation
- History of liver and kidney failure
- Neuromuscular disease
- Susceptibility to or family history of malignant hyperthermia
- Extensive denervation of skeletal muscle
- Chronic pain syndromes
- Taking medications that might interact with the effect of rocuronium or serum myoglobin difficult intubation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Statin use group Rocuronium patients taking statins for at least 3 months non statin use Rocuronium no history of taking statin
- Primary Outcome Measures
Name Time Method plasma myoglobin concentration 20 minutes after administration
- Secondary Outcome Measures
Name Time Method muscle pain 2 and 24 hours postoperatively serum potassium concentration 2 and 24 hours postoperatively plasma creatine phosphokinase concentration 2 and 24 hours postoperatively urine myoglobin and onset plus duration of succinylcholine block 2 and 24 hours postoperatively
Trial Locations
- Locations (1)
China Medical University
🇨🇳Shenyang, Liaoning, China