The Influence of Sweet Substrates on Hunger, Gastrointestinal Hormones and the Migrating Motor Complex
Not Applicable
Completed
- Conditions
- Healthy
- Registration Number
- NCT02891525
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- BMI<30 kg/m² for the lean volunteers
- Female or male subjects aged 18 to 60
- Subject is capable and willing to give informed consent
- Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception
Exclusion Criteria
- Female volunteer is pregnant or breastfeeding
- GI diseases, major abdominal surgery
- Volunteers that have food allergies, especially fructose intolerance
- Major psychiatric illnesses
- Volunteers that use drugs affecting the GI tract or the central nervous system
- Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
- Volunteers that have undergone surgical procedure for weight loss
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in gastrointestinal motility measured by antroduodenal high-resolution manometry 3 hours after administration, continuous measurement with high resolution manometry
- Secondary Outcome Measures
Name Time Method Change in gut hormone release measured by specific radioactive immunoassays 3 hours after administration, blood sample every 15 min Change in subjective hunger and satiety scores measured by visual analogue scales of 100 mm 3 hours after administration, assessment every 5 min