The Effect of Caloric and Non-caloric Sweeteners on Hunger, Gastrointestinal Hormones as Well as on Antral and Duodenal Motility

Universitaire Ziekenhuizen KU Leuven0 sites12 target enrollmentMarch 2015

ConditionsHealthy

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy
Sponsor: Universitaire Ziekenhuizen KU Leuven
Enrollment: 12
Primary Endpoint: Change in gastrointestinal motility measured by antroduodenal high-resolution manometry
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

In this study, the investigators aimed at evaluating the role of sweet taste receptors in the gastrointestinal tract (GIT). Intragastric administration of glucose, fructose or acesulfame-K were compared with placebo administration for their effects on gastrointestinal motility, gut hormone release (motilin, ghrelin, glucagon-like peptide-1 (GLP-1) and insulin) and hunger feelings.

Registry

clinicaltrials.gov

Start Date

March 2015

End Date

February 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Universitaire Ziekenhuizen KU Leuven

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•BMI\<30 kg/m² for the lean volunteers
•Female or male subjects aged 18 to 60
•Subject is capable and willing to give informed consent
•Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion Criteria

•Female volunteer is pregnant or breastfeeding
•GI diseases, major abdominal surgery
•Volunteers that have food allergies, especially fructose intolerance
•Major psychiatric illnesses
•Volunteers that use drugs affecting the GI tract or the central nervous system
•Volunteers suffering from an endocrine disease such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
•Volunteers that have undergone surgical procedure for weight loss

Outcomes

Primary Outcomes

Change in gastrointestinal motility measured by antroduodenal high-resolution manometry

Time Frame: 3 hours after administration, continuous measurement with high resolution manometry

Secondary Outcomes

Change in gut hormone release measured by specific radioactive immunoassays(3 hours after administration, blood sample every 15 min)
Change in subjective hunger and satiety scores measured by visual analogue scales of 100 mm(3 hours after administration, assessment every 5 min)