NCT04788680已完成不适用
Assessment of the Effects of Non-calorie Sweeteners on Gut Barrier and Inflammatory Markers Compared to Those of Sugars in Healthy Individuals
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 2
- 主要终点
- Changes in inflammatory markers.
研究概览
简要总结
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
详细描述
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No known history of metabolic diseases/disorders
- •BMI <25 kg/m2
排除标准
- •Food allergies or intolerances (esp. fructose intolerance and malabsorption)
- •Chronic disease of the gastrointestinal tract
- •Renal insufficiency
- •Taking drugs affecting lipid or glucose metabolism
结局指标
主要结局
Changes in inflammatory markers.
时间窗: 1 week
Changes in IL-6 plasma levels (ng/ml).
Changes in parameters of intestinal barrier function.
时间窗: 1 week
Changes in plasma endotoxin levels.
次要结局
- Changes in blood lipid levels.(1 week)
- Changes in blood pressure.(1 week)
- Changes in markers for glucose metabolism.(1 week)
研究者
Prof. Dr. Ina Bergheim
Principal Investigator
University of Vienna
研究点 (2)
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