Effects of Non-calorie Sweeteners, Mono- and Disaccharides on Intestinal Barrier Function
Not Applicable
Completed
- Conditions
- Dietary HabitsEndotoxemia
- Registration Number
- NCT04788680
- Lead Sponsor
- University of Vienna
- Brief Summary
The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
- Detailed Description
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
- No known history of metabolic diseases/disorders
- BMI <25 kg/m2
Exclusion Criteria
- Food allergies or intolerances (esp. fructose intolerance and malabsorption)
- Chronic disease of the gastrointestinal tract
- Renal insufficiency
- Taking drugs affecting lipid or glucose metabolism
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Changes in inflammatory markers. 1 week Changes in IL-6 plasma levels (ng/ml).
Changes in parameters of intestinal barrier function. 1 week Changes in plasma endotoxin levels.
- Secondary Outcome Measures
Name Time Method Changes in markers for glucose metabolism. 1 week Changes in fasting insulin levels (mU/l).
Changes in blood lipid levels. 1 week Changes in triglyceride levels.
Changes in blood pressure. 1 week Changes in systolic and diastolic blood pressure
Trial Locations
- Locations (1)
University of Vienna
🇦🇹Vienna, Austria
University of Vienna🇦🇹Vienna, Austria