The Relationship Between Adipokines, Obesity and Insulin Resistance in Women With Polycystic Ovarian Syndrome
- Conditions
- Polycystic Ovarian Syndrome
- Registration Number
- NCT02869750
- Lead Sponsor
- Ain Shams University
- Brief Summary
To evaluate possible clinical effects of adipokines , ( ghrelin, resistin and adiponectin), in obese and non-obese patients with polycystic ovary syndrome (PCOS).
- Detailed Description
Seventy selected PCOS patients will be recruited for this study, and will be divided into two groups based on their body mass index (BMI): 35 obese (BMI≥ 25 kg/m2, group A), 35 non-obese (BMI\<25 kg/m2, group B). In addition, 35 healthy non-obese women (BMI\<25 kg/m2) will bw enrolled as the control (group C). Serum levels of FSH (follicle stimulating hormone), LH (luteinizing hormone), T(testosterone), glucose, insulin, adiponectin, resistin and resistin will bw detected, and compared the differences of them among three groups
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 300
- Females with PCOS in child bearing age who presented at reproductive and endocrinology clinics at Ain Shams University Maternity Hospital
- Known androgen secreting tumor.
- PCO on ovarian stimulation medications
- PCO with any other medical illness.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum ghrelin level 24 hours measuring ghrelin, and ) in the three groups
serum resistin level 24 hours serum resistin level in the three groups
serum adiponectin level 24 hours serum adiponectin level in the three groups
- Secondary Outcome Measures
Name Time Method serum testosterone level 24 hours after labor serum testosterone level in three groups
Glucose/Insulin ratio 24 hours fasting glucose and insulin in three groups
Trial Locations
- Locations (1)
Ahmed Kotb
🇪🇬Cairo, Al Qahirah, Egypt