A Study of Intraoperative Transpulmonary and Intrathoracic Pressure Changes Associated With Ventilator Management of Tidal Volume and Positive End-expiratory Pressure (PEEP)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Mechanical Ventilation
- Sponsor
- University of California, Davis
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Intrathoracic Pressure
- Status
- Completed
- Last Updated
- 7 months ago
Overview
Brief Summary
A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.
Detailed Description
This study seeks to observe the effects of variations in ventilator settings on transpulmonary and intrathoracic pressures. More specifically, to observe the impact of variations in tidal volume from 6 mL/kg to 8 mL/kg and PEEP from 0 cm of water (H2O) to 5 cm H2O on transpulmonary and intrathoracic pressures monitored with an esophageal balloon catheter. The impact of this recommended decrease in tidal volume on the clinical utility of stroke volume variation (SVV) as a guide for fluid administration has not been previously examined.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for elective surgery requiring general anesthesia and endotracheal intubation.
Exclusion Criteria
- •Patients undergoing planned esophageal surgery
- •Patients with significant nasal or esophageal pathology
- •Adults unable to consent
- •Individuals who are not yet adults (infants, children, teenagers)
- •Pregnant women
- •Prisoners
Outcomes
Primary Outcomes
Intrathoracic Pressure
Time Frame: Intra-operative
Measure the intrathoracic pressure changes monitored with an esophageal pressure balloon catheter associated with intraoperative changes in mechanical ventilation parameters such as tidal volume and PEEP
Secondary Outcomes
- Stroke Volume Variation(Intra-operative)