The Ehlers-Danlos syndrome and regional anesthesia.

Completed

• Conditions: The Ehlers-Danlos syndrome is a group of rare genetic disorders caused by a defect in collagen synthesis. Several patients from the EDS patient organisation claimed that for them regional and local anesthesia did not work properly. Up to now there is no proof or explenation for this phenomenon.

• Registration Number: NL-OMON26445
• Lead Sponsor: /A

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

For the Ehlers-Danlos group:

1. people with all types of Ehlers-Danlos except type IV, proven by a geneticist or a comparably qualified person;

Exclusion Criteria

For Ehlers-Danlos patients:

1. Type IV Ehlers-Danlos;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Analgesia in the region of the ulnar nerve within 60 minutes after application of an ulnar nerve block.This will be demonstrated by increasing stimuli from a neurostimulator. If the subject does not regard 20 mA as painful there is of an adequate block.

Secondary Outcome Measures

Name	Time	Method
1. Analgesia from the subcutanous injections and the topical application of EMLA cream;<br /><br>2. Time of onset of analgesia;<br /><br>3. Time of end of analgesia;<br /><br>4. Duration of analgesia.