Antiepileptic Drugs in Elderly Patients
Recruiting
- Conditions
- Seizure, Epileptic
- Interventions
- Drug: antiepileptic drugs
- Registration Number
- NCT05459597
- Lead Sponsor
- Wei Zhao
- Brief Summary
The purpose is to study the population pharmacokinetics, effectiveness and safety of antiepileptic drug (phenytoin, carbamazepine, lamotrigine, levetiracetam, parempanel, etc) in elderly patients and recommend optimized dosage regimens.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 500
Inclusion Criteria
- Age ≥65 years old;
- Diagnosed with epilepsy;
- Using antiepileptic drugs for treatment;
Exclusion Criteria
- Patients who are expected to die within 48 hours;
- Patients with allergy to antiepileptic drugs;
- Patients receiving other investigational drugs;
- Other factors that the researcher considers unsuitable for inclusion.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Treatment antiepileptic drugs The use of antiepileptic drugs depends on the clinical practice.
- Primary Outcome Measures
Name Time Method The peak plasma drug concentration of antiepileptic drugs. at (0-4) h after oral administration To detect the peak plasma drug concentration of antiepileptic drugs.
The random plasma drug concentration of antiepileptic drugs. at (4-10) h after oral administration To detect the random plasma drug concentration of antiepileptic drugs.
The trough plasma drug concentration of antiepileptic drugs. at (1-2) h before the next administration To detect the trough plasma drug concentration of antiepileptic drugs.
- Secondary Outcome Measures
Name Time Method The frequency of seizures Through study completion, an average of 14 days The incidence of adverse drug reaction Through study completion, an average of 14 days
Trial Locations
- Locations (1)
Wei Zhao
🇨🇳Jinan, Shandong, China