ISRCTN76742797
Completed
Not Applicable
Short Pulse AntiRetroviral Therapy At human infection immunodeficiency virus (HIV) seroConversion: a Multicentre randomised trial of therapeutic intervention at primary HIV-1 infection
Imperial College London (UK)0 sites360 target enrollmentJuly 22, 2005
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Imperial College London (UK)
- Enrollment
- 360
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients of both sexes will be eligible for screening if they:
- •1\. Have reached the age of consent in their country for participating in a clinical study
- •2\. Are confirmed PHI by at least one of following criteria:
- •a. HIV positive antibody test within six\-months of an HIV negative antibody test (randomisation must take place within six months of previous negative test)
- •b. HIV antibody negative with positive Reverse Transcription Polymerase Chain Reaction (RT\-PCR)
- •c. Test 'incident' at low level (less than 0\.6\) using detuned assay (must be subtype B)
- •d. Equivocal HIV antibody test supported by a repeat test within a two\-week period showing a rising optical density
- •e. Have clinical manifestations of symptomatic HIV seroconversion illness supported by antigen positivity and less than four bands positive on Western Blot
- •3\. Able and willing to give written informed consent
Exclusion Criteria
- •Patients will not be eligible for screening if:
- •1\. Pregnant
- •2\. Unlikely to comply with protocol, and in particular adhere to therapeutic regimen
- •3\. Likely to use narcotics during the study period
- •4\. Antiretroviral therapy is indicated
- •5\. Antiretroviral therapy is contraindicated
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Not Applicable
Directly Observed antiretroviral Therapy for people living with Human Immunodeficiency Virus (HIV) and Acquired ImmunDeficiency Syndrome (AIDS): a randomised controlled trialISRCTN48682427Ministry of Health (Brazil)
Recruiting
Not Applicable
Antiviral therapy with direct acting anti-virals in hepatitis C patients.Chronic hepatitis CJPRN-UMIN000016288Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine500
Active, not recruiting
Phase 1
Short pulse antiretroviral therapy at HIV seroconversion:A multi-centre randomised trial of therapeutic intervention at primary HIV-1 infection. Tratamiento antirretroviral en pulsos cortos en la seroconversión por el VIH: ensayo clínico aleatorizado, multicéntrico, de intervención terapéutica en la infección primaria por VIH-1. - SPARTACprimary HIV infection infección primaria por el VIHMedDRA version: 9.1 Level: LLT Classification code 10058427 Term: Primary HIV infectionEUCTR2004-000446-20-ESImperial College371
Active, not recruiting
Phase 1
Essai pilote évaluant un traitement antirétroviral associant le MK-0518, le darunavir/ritonavir (TMC114/r) et l’etravirine (TMC125) chez les patients infectés par le VIH-1, en échec virologique et porteurs de virus multi-résistants. - TRIOEUCTR2007-000670-23-FRAgence nationale de recherches sur le sida et les hépatites virales. ANRS
Completed
Not Applicable
Highly Active Antiretroviral Therapy and Cardiovascular Risk factor profiles of HIV-infected Subjects in Nigeria: a cross-sectional studyHypertensionJPRN-UMIN000027983niversity of Warwick Benue State University Teaching Hospital400