A Study of Long-term Effects of Vedolizumab Subcutaneous in Adults With Ulcerative Colitis and Crohn's Disease
- Registration Number
- NCT02620046
- Lead Sponsor
- Takeda
- Brief Summary
The main aim of the study is to check for long-term side effects of Vedolizumab Subcutaneous (also known as Vedolizumab SC) in people with ulcerative colitis and Crohn's disease. Vedolizumab SC will be given as an injection just under the skin. This type of injection is called a subcutaneous injection or SC for short. Another aim of the study is to collect information on whether the participant's condition remains under control or improves during and after treatment with Vedolizumab SC.
Participants who previously took part in studies MLN0002SC-3027 or MLN0002SC-3031 will be invited to visit the study clinic. At this visit, the study doctor will check if each participant can take part in this study.
For those who can take part, participants will receive a subcutaneous injection of vedolizumab SC either once a week or once every 2 weeks. How often each participant receives vedolizumab SC will depend on their results from the previous study and on how active their condition is. Participants might be able to self-inject vedolizumab SC after being trained by the study doctors. During this study, the dose of vedolizumab SC might be increased for participants whose condition worsens.
Participants will continue treatment with vedolizumab SC until it is approved in their particular country, the participant decides to stop treatment, or the sponsor stops the study. If the sponsor stops the study before vedolizumab SC is approved in all countries, the sponsor will make sure all affected participants will have access to vedolizumab SC outside of the study.
After their final dose of vedolizumab SC, participants will visit the clinic 18 weeks later for a final check-up. Then, the clinic will telephone the participants 6 months after their final dose of vedolizumab SC to check if they have any health problems.
- Detailed Description
The drug being tested in this study is called vedolizumab subcutaneous (vedolizumab SC). Vedolizumab SC is being tested to assess its long-term safety and effectiveness in treating participants with UC or CD. This study will look at the long-term side effects and response/remission of UC and CD in participants who received vedolizumab SC in a prior vedolizumab SC study.
The study will enroll up to 692 patients. All participants enrolled in this study will have previously participated in the MLN0002SC-3027 or MLN0002SC-3031 study. Participants who completed the Maintenance Period (Week 52) in their previous study, or who did not achieve a clinical response at Week 6 but who did achieve a clinical response at Week 14 after having received a third vedolizumab IV infusion at Week 6 in their previous study, will receive open-label vedolizumab SC 108 mg, once every 2 weeks (Q2W). Participants who withdrew early from the Maintenance Period of their previous study due to disease worsening or need for rescue medications will receive open-label vedolizumab SC 108 mg, once every week (QW). Participants receiving SC 108 mg Q2W who experience treatment failure (disease worsening or need for rescue medications while in the current study will be dose escalated to vedolizumab SC 108 mg QW.
This multi-center trial will be conducted worldwide. Participation in this vedolizumab SC study will continue until vedolizumab SC becomes commercially available, the participant withdraws from the study, or the sponsor decides to close the study. Participants will make multiple visits to the clinic, plus a final visit 18 weeks after last dose of study drug for a follow-up assessment. Participants will also participate in a long-term safety follow-up, by phone, at 6 months after the last dose of study drug.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 746
- Prior participation in Study MLN0002SC-3027 or MLN0002SC-3031, and, in the opinion of the investigator, tolerated the study drug well. Early withdrawal from Study MLN0002SC-3027 or MLN0002SC-3031 must have been due to treatment failure during the Maintenance Period.
- Surgical intervention for IBD during or after participation in Study MLN0002SC-3027 or MLN0002SC-3031, or at any time during this study.
- Chronic or severe infection, or, any new, unstable, or uncontrolled cardiovascular, pulmonary, hepatic, renal, gastrointestinal, genitourinary, hematological, coagulation, immunological, endocrine/metabolic, neurologic, oncologic, or other medical disorder developed during or after participation in a prior vedolizumab study that, in the opinion of the investigator, would confound the study results or compromise participant safety.
- Withdrawal from Study MLN0002SC-3027 or MLN0002SC-3031 due to a study-drug related adverse event (AE).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group A: Vedolizumab SC 108 mg Q2W Vedolizumab SC Participants from studies MLN0002SC-3027 and MLN0002SC-3031 who: * Completed the Maintenance Period (Week 52), or * Were not randomized into Maintenance Period and achieved response at Week 14 after having received a third vedolizumab IV infusion at Week 6. Group B: Vedolizumab SC 108 mg QW Vedolizumab SC Participants from studies MLN0002SC-3027 and MLN0002SC-3031 who withdrew early from the Maintenance Period due to treatment failure. •Participants from current study who experience treatment failure while on study.
- Primary Outcome Measures
Name Time Method Number of Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) Adjusted by Duration of Participant's Exposure to Long-term Vedolizumab Treatment From start of study medication through 18 weeks after the last dose Number of TEAEs and SAEs adjusted by duration of exposure to study treatment scaled such that it provides an incidence rate of TEAEs and SAEs per 100-participant-years.
- Secondary Outcome Measures
Name Time Method Percentage of Participants with Ulcerative Colitis Achieving Clinical Remission From Week 0 (Day 1) up to availability of vedolizumab SC, withdrawal by participant, or study closure, up to 7 years Clinical remission is defined as a partial Mayo score of ≤ 2 with no individual subscore \>1.
Number of Adverse Events of Special Interest (AESIs) Adjusted by Duration of Participant's Exposure to Long-term Vedolizumab Treatment From start of study medication through 18 weeks after the last dose Number of AESIs adjusted by duration of exposure to study treatment scaled such that it provides an incidence rate of AESIs per 100-participant-years. AESIs include hypersensitivity reactions (including injections site reactions), serious infections, malignancies, hepatotoxicity (abnormal liver function test) and progressive multifocal leukoencephalopathy (PML).
Percentage of Participants with Crohn's Disease Achieving Clinical Response From Week 0 (Day 1) up to availability of vedolizumab SC, withdrawal by participant, or study closure, Up to 7 years Clinical response is defined as a decrease in HBI score of ≥3 points from baseline in CD participants (randomized early terminator CD participants only \[defined as randomized CD participants withdrawn from the parent study between Week 6 and Week 52\]).
Percentage of Participants with Crohn's Disease (CD) Achieving Clinical Remission From Week 0 (Day 1) up to availability of vedolizumab SC, withdrawal by participant, or study closure, Up to 7 years Clinical remission is defined as total HBI score of ≤4 points in CD participants only (defined as randomized CD participants withdrawn from the parent study between Week 6 and Week 52).
Percentage of Participants with Ulcerative Colitis Achieving Partial Mayo Scoring Clinical Response From Week 0 (Day 1) up to availability of vedolizumab SC, withdrawal by participant, or study closure, Up to 7 years Clinical response is defined as a decrease in the partial Mayo Score of at least 2 points and ≥25% from baseline, with an accompanying decrease in rectal bleeding subscore of ≥1 point from baseline or absolute rectal bleeding subscore of ≤1 point.
Trial Locations
- Locations (301)
AZ Groeninge - Kennedylaan
🇧🇪Kortrijk, Belgium
L & L Research Choices, Inc.
🇺🇸Miami, Florida, United States
Hospital Sao Vicente de Paulo
🇧🇷Passo Fundo, Rio Grande Do Sul, Brazil
St John of God Subiaco Hospital
🇦🇺Subiaco, Western Australia, Australia
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Morales Vargas Centro de Investigacion, S.C.
🇲🇽Leon, Guanajuato, Mexico
Centro de Investigacion Farmacologica del Bajio, S.C.
🇲🇽Leon, Guanajuato, Mexico
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Pest Megyei Flor Ferenc Korhaz
🇭🇺Kistarcsa, Hungary
MHAT - Silistra AD
🇧🇬Silistra, Bulgaria
"City Clinic UMHAC" EOOD
🇧🇬Sofia, Bulgaria
UMHAT 'Sveta Anna' AD
🇧🇬Sofia, Bulgaria
MC "Tsaritsa Yoanna' EOOD
🇧🇬Sliven, Bulgaria
Karolina Korhaz-Rendelointezet
🇭🇺Mosonmagyarovar, Hungary
MHAT "Hadzhi Dimitar", OOD
🇧🇬Sliven, Bulgaria
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Szent Janos Korhaz es Eszak-budai Egyesitett Korhazak
🇭🇺Budapest, Hungary
Fourth MHAT - Sofia EAD
🇧🇬Sofia, Bulgaria
Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz
🇭🇺Miskolc, Hungary
University Clinical Hospital Mostar
🇧🇦Mostar, Bosnia and Herzegovina
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
S.C Centrul de Gastroenterologie Dr. Goldis S.R.L
🇷🇴Timisoara, Romania
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Dr MJ Prins Practice
🇿🇦Cape Town, Western Cape, South Africa
Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez
🇲🇽Monterrey, Nuevo Leon, Mexico
Twoja Przychodnia-Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Mackay Memorial Hospital
🇨🇳Taipei, Taiwan
Vilnius University Hospital Santariskiu Clinics, Public Institution
🇱🇹Vilnius, Lithuania
Clinical Helth Centre Zvezdara
🇷🇸Belgrade, Serbia
Clinical Center Nis
🇷🇸Nis, Serbia
iBiomed Guadalajara
🇲🇽Zapopan, Jalisco, Mexico
Univerzitna nemocnica Bratislava, Nemocnica Ruzinov
🇸🇰Bratislava, Slovakia
KM Management spol. s r.o.
🇸🇰Nitra, Slovakia
Arizona Arthritis & Rheumatology Research, PLLC
🇺🇸Phoenix, Arizona, United States
Regionshospitalet Silkeborg
🇩🇰Silkeborg, Denmark
LHSC - University Hospital
🇨🇦London, Ontario, Canada
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Gastroenterology Associates, LLC
🇺🇸Baton Rouge, Louisiana, United States
Research Concierge, LLC
🇺🇸Owensboro, Kentucky, United States
Shafran Gastroenterology Center
🇺🇸Winter Park, Florida, United States
Carle Foundation Hospital
🇺🇸Urbana, Illinois, United States
Nature Coast Clinical Research, LLC
🇺🇸Inverness, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Cotton-O'Neil Clinical Research Center, Digestive Health
🇺🇸Topeka, Kansas, United States
Ehrhardt Clinical Research, LLC
🇺🇸Belton, Missouri, United States
Mayo Clinic - Rochester
🇺🇸Rochester, Minnesota, United States
Hospital Italiano
🇦🇷Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina
Allegiance Research Specialists, LLC
🇺🇸Milwaukee, Wisconsin, United States
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Monash Medical Centre Clayton
🇦🇺Bentleigh East, Victoria, Australia
PerCuro Clinical Research Ltd.
🇨🇦Victoria, British Columbia, Canada
Nemocnice Tabor a.s.
🇨🇿Tabor, Czechia
North Estonia Medical Centre Foundation
🇪🇪Tallinn, Estonia
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
🇭🇺Szekesfehervar, Hungary
HaEmek Medical Center
🇮🇱Afula, Israel
Barzilai Medical Center
🇮🇱Ashkelon, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
I.R.C.C.S Policlinico San Donato
🇮🇹San Donato Milanese, Milano, Italy
Azienda Ospedaliera Ospedale Cannizzaro
🇮🇹Catania, Italy
IRCCS Ospedale Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Foggia, Italy
Azienda Socio Sanitaria Territoriale Fatebenefratelli (Presidio Ospedale Sacco)
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria Policlinico G. Martino
🇮🇹Messina, Italy
Azienda Ospedaliera di Padova
🇮🇹Padova, Italy
Azienda Ospedaliera Vincenzo Cervello
🇮🇹Palermo, Italy
Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
Hiroshima University Hospital
🇯🇵Hiroshima-shi, Hiroshima-Ken, Japan
Yokoyama IBD Clinic
🇯🇵Nagoya-shi, Aichi-Ken, Japan
Fukuoka University Hospital
🇯🇵Fukuoka-shi, Fukuoka-Ken, Japan
Tokushukai Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Tokushukai Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Hyogo College of Medicine Hospital
🇯🇵Nishinomiya-shi, Hyogo-Ken, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu-shi, Kagawa-Ken, Japan
Iwate Medical University Hospital
🇯🇵Morioka-shi, Iwate-Ken, Japan
Gokeikai Ofuna Chuo Hospital
🇯🇵Kamakura-shi, Kanagawa-Ken, Japan
Osaka City General Hospital
🇯🇵Osaka-shi, Osaka-Fu, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu-shi, Shiga-Ken, Japan
Hamamatsu South Hospital
🇯🇵Hamamatsu-shi, Shizuoka-Ken, Japan
Saga University Hospital
🇯🇵Saga-shi, Saga-Ken, Japan
Medical Hospital, Tokyo Medical and Dental University
🇯🇵Bunkyo-ku, Tokyo-To, Japan
Kyorin University Hospital
🇯🇵Mitaka-shi, Tokyo-To, Japan
Jikei University Hospital
🇯🇵Minato-ku, Tokyo-To, Japan
JCHO Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Tokyo-To, Japan
Keio University Hospital
🇯🇵Shinjuku-ku, Tokyo-To, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama-shi, Wakayama-Ken, Japan
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Daegu, Gyeongsangbuk-do, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Klaipeda Republican Hospital, Public Institution
🇱🇹Klaipeda, Lithuania
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Klaipeda University Hospital, Public Institution
🇱🇹Klaipeda, Lithuania
Christus Muguerza Sur S.A. de C.V.
🇲🇽Monterrey, Nuevo Leon, Mexico
Academisch Medisch Centrum
🇳🇱Amsterdam, Netherlands
Universitair Medisch Centrum Groningen (UMCG)
🇳🇱Groningen, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
Erasmus Medisch Centrum
🇳🇱Rotterdam, Netherlands
Maastricht University Medical Center
🇳🇱Maastricht, Netherlands
SPZOZ Uniwersytecki Szpital Klin. nr 1 im.N.Barlickiego UM
🇵🇱Lodz, Poland
GASTROMED Sp. z o.o.
🇵🇱Lublin, Poland
NZOZ Vitamed
🇵🇱Bydgoszcz, Poland
SP ZOZ Wojewodzki Szpital Zespolony im. J. Sniadeckiego
🇵🇱Bialystok, Poland
Gabinet Endoskopii Przewodu Pokarmowego
🇵🇱Krakow, Poland
Santa Familia Centrum Badan, Profilaktyki i Leczenia
🇵🇱Lodz, Poland
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
Centralny Szpital Kliniczny MSW w Warszawie
🇵🇱Warszawa, Poland
Centrum Onkologii-Instytut im. M. Sklodowskiej Curie
🇵🇱Warszawa, Poland
Nzoz Vivamed
🇵🇱Warszawa, Poland
LexMedica Osrodek Badan Klinicznych
🇵🇱Wroclaw, Poland
Ars-Medica S.C Rybak Maria, Rybak Zbigniew
🇵🇱Wroclaw, Poland
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
TSBIH "Territorial Clinical Hospital"
🇷🇺Krasnoyarsk, Russian Federation
BHI of Omsk region "Clinical Oncology Dispensary"
🇷🇺Omsk, Russian Federation
SBEI HPE "Rostov State Medical University" of the MoH of the RF
🇷🇺Rostov-on-Don, Russian Federation
CI of Kyiv RC Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Ukraine
LLC "RIAT SPb"
🇷🇺Saint-Petersburg, Russian Federation
Military Medical Academy
🇷🇸Belgrade, Serbia
Clinical Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
Clinical Center Zemun
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Gastro I, s.r.o.
🇸🇰Presov, Slovakia
Gastroped s.r.o.
🇸🇰Kosice, Slovakia
Fakultna nemocnica s poliklinikou F.D. Roosevelta
🇸🇰Banska Bystrica, Slovakia
Dr CCM Ziady Practice
🇿🇦Pretoria, Gauteng, South Africa
Hospital Universitari Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Danderyds Sjukhus
🇸🇪Stockholm, Sweden
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Universitari de Girona Dr Josep Trueta
🇪🇸Girona, Spain
Complejo Hospitalario de Pontevedra
🇪🇸Pontevedra, Spain
Karolinska Universitetssjukhuset - Solna
🇸🇪Stockholm, Sweden
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Ankara University Medical Faculty
🇹🇷Ankara, Turkey
Gazi University Medical Faculty
🇹🇷Ankara, Turkey
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty
🇹🇷Istanbul, Turkey
Marmara University Pendik Research and Training Hospital
🇹🇷Istanbul, Turkey
Kocaeli Derince Training and Research Hospital
🇹🇷Kocaeli, Turkey
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
RCNECRCH Dept of Surgery, SHEI Ukr BSMU
🇺🇦Chernivtsi, Ukraine
SI Institute of Gastroenterology of NAMSU Dept of Stomach & Duodenum Diseases, D&ThN SI DMA of MoHU
🇺🇦Dnipro, Ukraine
Regional CH Dep of Gastroenterology SHEI Ivano-Frankivsk NMU
🇺🇦Ivano-Frankivsk, Ukraine
MI of Healthcare Kyiv RCH P.L. Shupyk NMA of PGE
🇺🇦Kyiv, Ukraine
CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC
🇺🇦Kharkiv, Ukraine
CI A.and O. Tropiny City Clinical Hospital
🇺🇦Kherson, Ukraine
Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU
🇺🇦Kyiv, Ukraine
Communal City Clinical Hospital of Ambulance, Dept of Therapy #1 D.Halytskyi Lviv NMU
🇺🇦Lviv, Ukraine
CI Odesa Regional Clinical Hospital
🇺🇦Odesa, Ukraine
Private Small Enterprise Medical Center Pulse
🇺🇦Vinnytsia, Ukraine
Ternopil University Hospital
🇺🇦Ternopil, Ukraine
Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU
🇺🇦Vinnytsia, Ukraine
Royal Devon and Exeter Hospital (Wonford)
🇬🇧Exeter, Devon, United Kingdom
CI City Hospital #1
🇺🇦Zaporizhzhia, Ukraine
St George's Hospital
🇬🇧London, Greater London, United Kingdom
University Hospital Coventry
🇬🇧Coventry, West Midlands, United Kingdom
Kinshukai Infusion Clinic
🇯🇵Osaka-shi, Osaka-Fu, Japan
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Tokyo-To, Japan
Arkansas Primary Care Clinic, PA
🇺🇸Little Rock, Arkansas, United States
Rocky Mountain Clinical Research, LLC
🇺🇸Wheat Ridge, Colorado, United States
Medical Research Center of Connecticut, LLC
🇺🇸Hamden, Connecticut, United States
Middlesex Gastroenterology Associates
🇺🇸Middletown, Connecticut, United States
Florida Center for Gastroenterology
🇺🇸Largo, Florida, United States
BRCR Medical Center, Inc.
🇺🇸Pembroke Pines, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Gastroenterology Associates of Central Georgia
🇺🇸Macon, Georgia, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Grand Teton Research Group, PLL
🇺🇸Idaho Falls, Idaho, United States
Tri-State Gastroenterology Associates
🇺🇸Crestview Hills, Kentucky, United States
Lafayette General Medical Center
🇺🇸Lafayette, Louisiana, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
Metropolitan Gastroenterology Group, PC, Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Gastroenterology Associates of Western Michigan, P.L.C.
🇺🇸Wyoming, Michigan, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Digestive Health Center PA
🇺🇸Ocean Springs, Mississippi, United States
Huron Gastroenterology Associates
🇺🇸Ypsilanti, Michigan, United States
Long Island Clinical Research Associates
🇺🇸Great Neck, New York, United States
AGA Clinical Research Associates, LLC
🇺🇸Egg Harbor Township, New Jersey, United States
Premier Medical Group of the Hudson Valley, PC
🇺🇸Poughkeepsie, New York, United States
Dayton Gastroenterology, Inc
🇺🇸Dayton, Ohio, United States
Gastro-Enterology Research of Lima
🇺🇸Lima, Ohio, United States
Main Line Gastroenterology Associates
🇺🇸Perkasie, Pennsylvania, United States
Gastroenterology Center of the MidSouth PC
🇺🇸Germantown, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
San Antonio Gastroenterology
🇺🇸San Antonio, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
Virginia Mason Seattle Main Clinic
🇺🇸Seattle, Washington, United States
Centro Medico Viamonte SRL
🇦🇷Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina
Centro de Investigaciones Medicas Mar del Plata
🇦🇷Mar del Plata, Buenos Aires, Argentina
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Tennyson Centre Day Hospital
🇦🇺Kurralta Park, South Australia, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Queensland, Australia
Ballarat Base Hospital
🇦🇺Ballarat, Victoria, Australia
St Vincent's Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
St Frances Xavier Cabrini Hospital
🇦🇺Malvern, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Melbourne, Victoria, Australia
Imeldaziekenhuis
🇧🇪Bonheiden, Belgium
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
AZ Sint-Lucas
🇧🇪Brugge, Belgium
ZNA Jan Palfijn
🇧🇪Merksem, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
University Clinical Centre of the Republic of Srpska
🇧🇦Banja Luka, Bosnia and Herzegovina
Clinique Saint-Pierre
🇧🇪Ottignies, Belgium
AZ Delta
🇧🇪Roeselare, Belgium
Instituto Goiano de Gastroenterologia e Endoscopia Digestiva Ltda
🇧🇷Goiania, Goias, Brazil
HUGG - Hospital Universitario Gaffree e Guinle
🇧🇷Rio de Janeiro, Rio Do Janeiro, Brazil
HUCFF-UFRJ - Hospital Universitario Clementino Fraga Filho - Universidade Federal do Rio de Janeiro
🇧🇷Rio de Janeiro, Rio Do Janeiro, Brazil
Faculdade de Medicina do ABC
🇧🇷Santo Andre, Sao Paulo, Brazil
UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
🇧🇷Botucatu, Sao Paulo, Brazil
Options Health Research
🇺🇸Tulsa, Oklahoma, United States
Atlanta Gastroenterology Specialists, PC
🇺🇸Suwanee, Georgia, United States
Irmandade da Santa Casa da Misericordia de Santos
🇧🇷Santos, Sao Paulo, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, Sao Paulo, Brazil
"MHAT Avis - Medica" OOD
🇧🇬Pleven, Bulgaria
UMHAT 'Dr. Georgi Stranski', EAD
🇧🇬Pleven, Bulgaria
Second MHAT - Sofia AD
🇧🇬Sofia, Bulgaria
Medical Center "Excelsior", OOD
🇧🇬Sofia, Bulgaria
UMHAT "Sv. Ivan Rilski", EAD
🇧🇬Sofia, Bulgaria
UMHAT 'Tsaritsa Yoanna - ISUL', EAD
🇧🇬Sofia, Bulgaria
Military Medical Academy - MHAT - Sofia
🇧🇬Sofia, Bulgaria
Medical Center "Nov Rehabilitatsionen Tsentar", EOOD
🇧🇬Stara Zagora, Bulgaria
Zeidler Ledcor Centre - University of Alberta
🇨🇦Edmonton, Alberta, Canada
LHSC - Victoria Hospital
🇨🇦London, Ontario, Canada
Clinical Hospital Centre Rijeka
🇭🇷Rijeka, Croatia
Toronto Digestive Disease Associates, Inc.
🇨🇦Vaughan, Ontario, Canada
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
Special Hospital Medico
🇭🇷Rijeka, Croatia
University hospital centre Zagreb
🇭🇷Zagreb, Croatia
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
CCBR - Czech Brno, s.r.o..
🇨🇿Brno, Czechia
Hepato-Gastroenterologie HK s.r.o.
🇨🇿Hradec Kralove, Czechia
A-SHINE s.r.o.
🇨🇿Plzen, Czechia
CLINTRIAL s.r.o.
🇨🇿Praha 10, Czechia
Odense Universitetshospital
🇩🇰Odense C, Denmark
Axon Clinical s.r.o.
🇨🇿Praha 5, Czechia
CCBR Czech Prague, s.r.o.
🇨🇿Praha 3, Czechia
Tartu University Hospital
🇪🇪Tartu, Estonia
LMU - Campus Grosshadern
🇩🇪Muenchen, Bayern, Germany
Klinikum der Johann Wolfgang Goethe-Universitaet
🇩🇪Frankfurt, Hessen, Germany
Universitaetsklinikum Koeln
🇩🇪Koeln, Nordrhein Westfalen, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
🇩🇪Mainz, Rheinland Pfalz, Germany
Universitaetsklinikum Magdeburg A.oe.R
🇩🇪Magdeburg, Sachsen Anhalt, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Kiel
🇩🇪Kiel, Schleswig Holstein, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Niedersachsen, Germany
EUGASTRO GmbH
🇩🇪Leipzig, Sachsen, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
🇩🇪Lubeck, Schleswig Holstein, Germany
Charite - Campus Virchow-Klinikum
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend
🇩🇪Berlin, Germany
Krankenhaus Waldfriede e. V.
🇩🇪Berlin, Germany
Obudai Egeszsegugyi Centrum Kft.
🇭🇺Budapest, Hungary
Markhot Ferenc Oktatokorhaz es Rendelointezet
🇭🇺Eger, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza
🇭🇺Gyula, Hungary
Tolna Megyei Balassa Janos Korhaz
🇭🇺Szekszard, Hungary
Soroka University Medical Center
🇮🇱Beer Sheva, Israel
Rambam Health Care Campus
🇮🇱Haifa, Israel
Pecsi Tudomanyegyetem
🇭🇺Pecs, Hungary
Wolfson Medical Center
🇮🇱Holon, Israel
Kaplan Medical Center
🇮🇱Rechovot, Israel
Galilee Medical Center
🇮🇱Nahariya, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
A.O.U. Policlinico di Modena
🇮🇹Modena, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliera Universitaria "Federico II"
🇮🇹Napoli, Italy
Azienda Ospedaliera San Camillo Forlanini
🇮🇹Roma, Italy
Ehime Prefectural Central Hospital
🇯🇵Matsuyama-shi, Ehime-Ken, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino-shi, Fukuoka-Ken, Japan
Toho University Sakura Medical Center
🇯🇵Sakura-shi, Chiba-Ken, Japan
Sapporo-Kosei General Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Kurume University Hospital
🇯🇵Kurume-shi, Fukuoka-Ken, Japan
Okayama University Hospital
🇯🇵Okayama-shi, Okayama-Ken, Japan
Sociedad de Metabolismo y Corazon S.C
🇲🇽Veracruz, Mexico
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
🇲🇽Durango, Mexico
SP CSK im. prof. K. Gibinskiego SUM
🇵🇱Katowice, Poland
LLC "Novosibirsk GastroCenter"
🇷🇺Novosibirsk, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
FSBIH "Central Clinical Hospital of Russian Academy of Sciences"
🇷🇺Moscow, Russian Federation
SBEIHPE Novosibirsk State Medical University
🇷🇺Novosibirsk, Russian Federation
SPb SBIH "City Hospital of Saint Martyr Elizaveta"
🇷🇺St. Petersburg, Russian Federation
SPb SBIH "City Hospital # 40 of Kurortnyi region"
🇷🇺Sestroretsk, Russian Federation
Clinical Center of Vojvodina
🇷🇸Novi Sad, Serbia
Dr JP Wright Practice
🇿🇦Cape Town, Western Cape, South Africa
Haydarpasa Numune Training and Research Hospital
🇹🇷Istanbul, Turkey
Acibadem Fulya Hospital
🇹🇷Istanbul, Turkey
Norfolk and Norwich University Hospital
🇬🇧Norwich, Norfolk, United Kingdom
MCIC MC LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
Royal Free Hospital
🇬🇧London, Greater London, United Kingdom
Whipps Cross University Hospital
🇬🇧London, Greater London, United Kingdom
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, Shropshire, United Kingdom
Royal Wolverhampton hospital
🇬🇧Wolverhampton, West Midlands, United Kingdom
Medical University of South Carolina (MUSC)
🇺🇸Charleston, South Carolina, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States