Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation

Not Applicable

Completed

• Conditions: Hypotension After Reperfusion in Liver Transplantation
• Interventions: Drug: epinephrine; Drug: placebo control; Drug: phenylephrine

• Registration Number: NCT01080625
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-03-02
• Study First Submitted QC: 2010-03-02
• Study First Posted: 2010-03-04
• Study Start: 2010-04
• Primary Completion: 2011-09
• Study Completion: 2011-10
• Results First Submitted: 2012-02-13
• Results First Submitted QC: 2012-03-17
• Results First Posted: 2012-04-12
• Status Verified: 2012-05
• Last Update Submitted: 2012-05-01
• Last Update Posted: 2012-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• adults scheduled to undergo liver transplantation

Exclusion Criteria

• pediatric liver transplantation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
epinephrine	epinephrine	10 mcg of epinephrine is administered iv at the time of reperfusion
control	placebo control	10 ml of normal saline is administered at the time of reperfusion
phenylephrine	phenylephrine	100 mcg of phenylephrine is administered at the time of reperfusion

Primary Outcome Measures

Name	Time	Method
Occurrence of Postreperfusion Syndrome (PRS)	immediately after reperfusion	the number of patients who showed PRS (hypotension defined as \< 30% of baseline mean arterial pressure \[MAP\] lasting over 1 min immediately after reperfusion of liver graft) was divided by the total number of patients enrolled for each group

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of