Effect of Preventive Medicine on the Postreperfusion Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- Occurrence of Postreperfusion Syndrome (PRS)
研究概览
简要总结
Postreperfusion syndrome (PRS) is a relatively common phenomenon in patients undergoing liver transplantation which is characterized by an acute drop in blood pressure immediately after the prefusion is restored to the transplanted liver. We hypothesized that PRS would be prevented when phenylephrine or epinephrine is administered immediately prior to reperfusion in liver transplantation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adults scheduled to undergo liver transplantation
排除标准
- •pediatric liver transplantation
研究组 & 干预措施
phenylephrine
100 mcg of phenylephrine is administered at the time of reperfusion
干预措施: phenylephrine (Drug)
epinephrine
10 mcg of epinephrine is administered iv at the time of reperfusion
干预措施: epinephrine (Drug)
control
10 ml of normal saline is administered at the time of reperfusion
干预措施: placebo control (Drug)
结局指标
主要结局
Occurrence of Postreperfusion Syndrome (PRS)
时间窗: immediately after reperfusion
the number of patients who showed PRS (hypotension defined as \< 30% of baseline mean arterial pressure \[MAP\] lasting over 1 min immediately after reperfusion of liver graft) was divided by the total number of patients enrolled for each group
次要结局
未报告次要终点
研究者
Chul-Woo Jung
Assistant professor
Seoul National University Hospital