Paraorbital-occipital Alternating Electric Current Stimulation in Patients With Optic Neuropathy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Visual Impairment
- Sponsor
- University of Magdeburg
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- Detection accuracy (DA) change in percent over baseline within defective visual field sectors
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Non-invasive brain stimulation can increase cortical excitability in the visual system, but it is not known if this is of clinical value. The investigators now assessed if repetitive, transcranial alternating current stimulation (rtACS) can improve visual field size in patients with optic nerve damage. The investigators hypothesized that rtACS would improve visual functions with the defective visual field sectors of the visual field (primary outcome measure).
Detailed Description
exploratory, randomized, controlled study
Investigators
Bernhard A. Sabel
Director, Inst Med Psychol
University of Magdeburg
Eligibility Criteria
Inclusion Criteria
- •residual vision
- •patients with optic nerv lesion
- •lesion age at least 6 months
- •stable visual field defect
Exclusion Criteria
- •electric or electronic implants such as pace maker
- •any metal artefacts in head and truncus
- •epilepsia
- •photosensitive epilepsy as determines by EEG
- •autoimmune illnesses in acute stage
- •mental diseases such e.g. schizophrenia etc.
- •diabetes causing diabetic retinopathy
- •addiction
- •high blood pressure
- •unstable or high level intraocular pressure (i.e. \> 27 mmHg)
Outcomes
Primary Outcomes
Detection accuracy (DA) change in percent over baseline within defective visual field sectors
Time Frame: between baseline and 60 days after stimulation
Central visus fields were assessed with computer based high-resolution perimetry (HRP). Based on such plots, areas of the visual field were characterized as intact, partially damaged or absolutely impaired (blind).
Secondary Outcomes
- Visual Parameters 2(baseline to 60 days after stimulation)
- Visual Parameters 1(baseline to 60 days after stimulation)
- Visual Parameters 3(baseline to 60 days after stimulation)
- Visual Parameters 4(baseline to 60 days after stimulation)
- EEG parameters(baseline to 60 days after stimulation)