Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Complete Hemianopia
- Sponsor
- University of Magdeburg
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- detection accuracy (%) in visual field measures over baseline
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Visual field areas, which are not absolutely blind, are hypothesized to have some residual capacities that constitute their potential for vision restoration. Vision restoration can be achieved by varies methods including behavioral training and electrical brain stimulation such as transcranial direct current stimulation (tDCS) and repetitive transorbital alternating current stimulation (rtACS) which are able to influence the excitability and activity of cortical areas.
It is hypothesized that transorbital alternating current stimulation (tACS) can improve the residual field of vision in patients with post-chiasmatic lesions.
Investigators
Bernhard A. Sabel
Prof. Dr.
University of Magdeburg
Eligibility Criteria
Inclusion Criteria
- •lesion of the tractus opticus or of the visual cortex
- •lesion age \> 6 months
- •stable visual field defect with residual vision
Exclusion Criteria
- •electric or electronic implants, e.g. heart pacer
- •any metal artefacts in the head
- •Auto-immune diseases in acute stage
- •mental diseases, e.g. schizophrenia etc.
- •diabetic retinopathy
- •addictive diseases
- •blood pressure above 160/100 mmHg
- •instable or high level of intraocular pressure above 27 mmHg
- •retinitis pigmentosa
- •pathological nystagmus
Outcomes
Primary Outcomes
detection accuracy (%) in visual field measures over baseline
Time Frame: baseline to 8 weeks after stimulation
visual stimuli detection accuracy in residual and absolutely defect visual field will be assessed using computer-based high resolution perimetry (HRP)
Secondary Outcomes
- detection accuracy (%) in the intact visual field over baseline(baseline to 8 weeks after stimulation)
- reaction time (ms)(baseline to 8 weeks after stimulation)
- EEG parameters(baseline to 8 weeks after stimulation)
- conventional perimetry(baseline to 8 weeks after stimulation)
- visual acuity (LogRAD)(baseline to 8 weeks after stimulation)