Outcome of Cataract Surgery With Uveitis

Not Applicable

• Conditions: Cataract; Complicata
• Interventions: Procedure: cataract surgery

• Registration Number: NCT04333069
• Lead Sponsor: Assiut University

Brief Summary

Aim of the study is to evaluate outcome of cataract surgery in different types of uveitis as regarding best corrected visual acuity (BCVA) and rate of post operative complications.

Detailed Description

Cataract is the main cause of reversible blindness in patients with uveitis. Cataract occurs in up to 50% to 70% of patients with uveitis.

Preoperative complications, including anterior synechiae, posterior synechiae, and pupillary membrane formation, may increase surgical challenges. In addition, recurrent inflammation increases the incidence of postoperative complications and often affects the visual prognosis. In recent years, phacoemulsification with intra ocular lens (IOL)implantation has become the main surgical method for treating uveitis (complicated cataract), and the visual prognosis of patients who undergo this procedure is usually favorable.

Surgical treatment may be effective but is associated with higher rates of complication than in non uveitic eyes. Cystoid macular edema (CME) is the most common complication cataract surgery in the general population. Although, in most cases, the macular edema is self-limited, in rare cases it can lead to long-term visual deterioration that is difficult to treat.

Another common complication after cataract surgery is posterior capsule opacification (PCO) , leading to symptoms of glare or blurred vision, reduced visual acuity, or impaired posterior segment exam. Factors that are critical in the development of PCO include surgical technique, type of implanted intra ocular lens (IOL) either foldable hydrophilic acrylic, hydrophobic acrylic or silicone and postoperative control of uveitis

Study Timeline

• Status Verified: 2020-03
• Study First Submitted: 2020-03-28
• Study First Submitted QC: 2020-04-01
• Last Update Submitted: 2020-04-01
• Study First Posted: 2020-04-03
• Last Update Posted: 2020-04-03
• Study Start: 2020-04-10
• Primary Completion: 2022-05-20
• Study Completion: 2022-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Visually significant cataract ( means opacification of the crystalline lens adequate to interfere with vision)in patients with uveitis controlled for at least 1month.

Exclusion Criteria

• Irreversible pathology affecting outcome e.g. macular scar ,optic atrophy, and retinal detachment.
• Patients with active uveitis (means inflammation inside the eye).
• Patients less than 16 years old.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Uncorrected and best corrected visual acuity	cataract surgery	Measuring of uncorrected and best corrected visual acuity after phaco emulsification and irrigation aspiration cataract surgery

Primary Outcome Measures

Name	Time	Method
final postoperative uncorrected visual acuity (UCVA)	6months post operative	post operative uncorrected visual acuity which mean visual acuity without spectacle correction
Final post operative best corrected visual acuity (BCVA)	6months post operative	Post operative visual acuity with spectacle correction

Secondary Outcome Measures

Name	Time	Method
incidence of postoperative complications	6 months post operative	cystoid macular edema which mean inflammation, swelling and collection of fluid inside macula) .
Reactivation of intraocular inflammation	6 months post operative	Appearance of inflammatory activity inside the eye after period of quiescence of at least 6 months