Exploring the Neural Basis of Cognitive Processing in the Human Brain: Single Neuron Recordings in Depth-electrode Candidates for Epilepsy Surgery

Recruiting

Conditions: epilepsy
seizures
10039911

Registration Number: NL-OMON54764

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

Epilepsy patients with macro-electrode and micro-wire implants
18 years or older
patients able to perform the experiments at an adequate level
patients need to be mentally competent

Exclusion Criteria

IQ<70
serious memory impairment
serious visual impairment
for the fMRI: regular contraindications for MRI

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the macro- and microelectrode recordings of<br /><br>different brain areas during the performance of simple behavioural tasks and<br /><br>during stimulation of macro-electrode contacts. An important goal is to relate<br /><br>performance on the tasks to the neural data. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study parameters are the single- and multi-unit recordings and<br /><br>LFP during stimulation of the macro-contacts (if this is performed as part of<br /><br>the clinical assessment) and a functional MRI scan if an electrode is located<br /><br>in a visual area. We will also use data from two self/report questionnaires<br /><br>which will be administered both pre- and post-implantation. We will use the<br /><br>Beck Anxiety Inventory to assess anxiety and the Beck Depressivity Index to<br /><br>assess depression after the operation. These scores can be used to as<br /><br>co-regressors in our neural analyses. We will administer the questionnaire 3-4<br /><br>days post-operatively to assess the patient*s state during the experimental<br /><br>phase at which we record the majority of our data. </p><br>