Investigating changes in brain networks and cognition after heart surgery
- Conditions
- Cardiac disease/coronary artery bypass graftingCirculatory System
- Registration Number
- ISRCTN68065962
- Lead Sponsor
- niversity Hospitals Bristol NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
1. Aged between 60-75 years
2. Electively referred for isolated coronary artery bypass grafting
1. Prisoners and adults lacking capacity to consent
2. Contraindications to MR (implanted electronic devices, metallic foreign bodies, claustrophobia, body weight >140 kg or waist perimeter exceeding manufacturer's recommendations and others according to manufacturer’s recommendations and generally accepted guidelines)
3. Patients with a neurological disorder (e.g. epilepsy, Alzheimer’s, dementia and Parkinson’s disease)
4. Patients with a diagnosed psychiatric disorder (e.g. schizophrenia, psychosis), drug or alcohol addiction
5. Patients with an already identified as having cognitive impairment (e.g. memory and/or attentional deficits) as defined by psychometric assessment or a preoperative Mini-mental State Examination score < 24. The Mini-mental State Examination will be adminstered after consent but prior to any of the cognitive assessements or fMRI scan
6. Patients who have previously sustained a stroke, intra-cerebral haemorrhage, acquired brain injury
7. Patients unable to complete the cognitive assessments required for the trial e.g. due to language difficulties, visual or hearing impairment
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method