The Onset Time of Rocuronium in Emergency and Elective Surgery
- Conditions
- Inguinal HerniaAcute Appendicitis
- Interventions
- Other: Ringer LactateDevice: Acceleromyography device
- Registration Number
- NCT02634255
- Lead Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
- Brief Summary
Rocuronium, a nondepolarizing neuromuscular blocking agent, is used in general anesthesia to provide conditions for endotracheal intubating. Recommended dose is 0,6 mg/kg and 90 seconds after intravenous injection, patients can be intubated.
Anxiety levels may vary in patients undergoing emergency and elective surgery. Patients undergoing emergency surgery may display exaggerated laryngoscopic responses. The purpose of this study is to investigate the effect of patient anxiety levels on the onset time of rocuronium in terms of anxiety scores and train of four (TOF) 0.1 times.
- Detailed Description
After obtaining ethics committee approval, American Society of Anesthesiologists physiological status 1 (ASA 1) patients, undergoing elective inguinal hernia repair and acute appendectomy, will be included to trial.
Patients will be taken to the operating room without premedication. Spielberger's State-Trait Anxiety Inventory (STAI) will be administered to patients for determining anxiety level.
Electrocardiogram, blood pressure and peripheric oxygen saturation (SpO2) will be monitored. After opening intravenous access on hand dorsum, ringer lactate solution will be given. Neuromuscular monitoring and drug injections will be done as described in "Good Clinical Research Practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents".
TOF-Guard SX acceleromyograph (Organon-Teknika) will be monitored on corrugator supercilii muscle because of its sensitivity to laryngeal muscles. In induction of anesthesia, propofol 2 mg kg-1 and fentanyl 1 mcg kg-1 will be administered intravenously. After loss of conscious, TOF-Guard SX will be calibrated and then 0.6 mg kg-1 rocuronium will be administered in 5 seconds. 20 milliampere (mA) current TOF stimulation (200 ms, square wave, 2 Hz for 1.5 s) will be repeated in every 15 s. Patients will be intubated in TOF 0.1 time.
STAI score, heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, SpO2, TOF 0.1 time and intubation conditions will be compared between two groups.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- BMI 18,5-24,9
- ASA 1
- Allergy to used drugs during anesthesia
- Neuromuscular disease
- Liver and kidney failure
- Heart failure
- Anticipated difficult airway
- Using aminoglycosides
- BMI<18,5 and BMI>25
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Rocuronium elective surgery Rocuronium elective surgery patients undergoing inguinal herniorrhaphy Rocuronium elective surgery Propofol patients undergoing inguinal herniorrhaphy Rocuronium elective surgery Fentanyl patients undergoing inguinal herniorrhaphy Rocuronium elective surgery Ringer Lactate patients undergoing inguinal herniorrhaphy Rocuronium elective surgery Acceleromyography device patients undergoing inguinal herniorrhaphy Rocuronium emergency surgery Rocuronium emergency surgery patients undergoing appendectomy Rocuronium emergency surgery Ringer Lactate patients undergoing appendectomy Rocuronium emergency surgery Acceleromyography device patients undergoing appendectomy Rocuronium emergency surgery Fentanyl patients undergoing appendectomy Rocuronium emergency surgery Propofol patients undergoing appendectomy
- Primary Outcome Measures
Name Time Method Train of Four Ratio (TOF 0.1) 90 seconds after induction anxiety score 15 minutes before induction
- Secondary Outcome Measures
Name Time Method