Exercise Training and Metabolic Syndrome

Not Applicable

Completed

• Conditions: Metabolic Syndrome
• Interventions: Behavioral: Aerobic interval training

• Registration Number: NCT03036332
• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho

Brief Summary

The present study aimed to determine the effects of 16 weeks of aerobic interval training on quality of life and a set of clinical biomarkers.

Detailed Description

Besides the traditional metabolic syndrome risk factors (dyslipidemia, raised blood pressure, central obesity and dysglycemia) subclinical disorders related to chronic inflammation and cell damage have been reported on metabolic syndrome. Therefore, regarding the systemic feature of metabolic syndrome, we investigated an new approach of aerobic interval training on several clinical biomarkers widely used. Such training used differs from current aerobic protocols in order to attenuate metabolic and musculoskeletal overload on untrained and unhealthy subjects.

Study Timeline

• Study Start: 2015-06-01
• Primary Completion: 2016-12-10
• Study Completion: 2016-12-10
• Status Verified: 2017-01
• Study First Submitted: 2017-01-26
• Study First Submitted QC: 2017-01-27
• Last Update Submitted: 2017-01-27
• Study First Posted: 2017-01-30
• Last Update Posted: 2017-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 53

Inclusion Criteria

• Having metabolic syndrome according to international diabetes foundations definition (IDF).
• Age between 35 - 60 years and untrained subjects.

Exclusion Criteria

• Musculotendinous or osteoarticular injuries in the lower limbs and/or spine
• Chronic pulmonary diseases
• Neurological disorders
• Kidney failure
• High-risk cardiovascular diseases (Unstable angina pectoris, Uncompensated heart failure, complex ventricular arrhythmias or myocardial infarction during the last month).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
intervention	Aerobic interval training	Aerobic interval training

Primary Outcome Measures

Name	Time	Method
Pro-inflammatory marker	16 weeks	Serum levels of C-reactive protein

Secondary Outcome Measures

Name	Time	Method
Quality of life	16 weeks	The Medical Outcomes Study-Short Form 36 (SF-36)
A set of clinical biomarkers	16 weeks	Serum levels lof Homocysteine; Creatinine, Creatine kinase (ck); creatine kinase MB (ck-mb); Troponin t; aspartate aminotransferase; alanine aminotransferase; and complete blood count.