Prognostic Value of Endothelial Dysfunction and Coronary Complexity
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT00737945
- Lead Sponsor
- Kumamoto University
- Brief Summary
The investigators test the additional clinical value of the physiological assessment of endothelial function to the morphological assessment of coronary complexity and classical risk score in predicting cardiovascular events.
- Detailed Description
The investigators enroll consecutive, stable high risk patients for cardiovascular events. The reactive hyperemia peripheral arterial tonometry index (RHI) was measured before coronary angiography and coronary lesions were assessed angiographically by SYNTAX Scoring system. The investigators all subjects and examined the occurrence of cardiovascular events (CV death, non-fatal myocardial infarction and ischemic stroke, unstable angina pectoris, hospitalization for HF, coronary revascularization, or non-fatal aortic and peripheral vascular disease).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1000
- Stable, high-risk patients with diabetes mellitus, or more than two conventional coronary risk factors, who are referred for coronary angiography because of angina-like chest symptoms.
- An ejection fraction < 50%
- Moderate to severe valvular heart disease
- Cardiomyopathy
- Allergy to latex
- Significant endocrine, hepatic, renal, or inflammatory disease
- cerebrovascular disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cardiovascular event Outcome is assessed 1 to 4 years after entry Cardiovascular event consists of cardiovascular death, myocardial infarction, unstable angina, ischemic stroke, coronary revascularization, hospitalization for heart failure, aortic disease and peripheral arterial disease.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kumamoto University Hospital
🇯🇵Kumamoto, Japan