Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia

• Conditions: Suxamethonium Sensitivity; Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified

• Registration Number: NCT03415607
• Lead Sponsor: University Hospital, Caen

Brief Summary

Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content. Whereas other myorelaxant agents are monitored with train of four stimulation to assess onset and duration, few anesthesiologists use train of four stimulation for onset of succinylcholine, as the anesthesiologists evaluate the effect with the time from injection (usually one minute) and the muscle fasciculation due to the release of acetylcholine.

The data available on onset duration of this drug are old and bases on only few studies, but the succinylcholine if sometime harmful (anaphylaxis , cardiac arrest, bronchospasm).

The investigators want to assess the onset time of succinylcholine with an objective toll , the train of four stimulation, and evaluate if the clinical judgment of the anesthesiologist is reliable to predict an adequate moment for endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2017-11
• Study Start: 2017-11-06
• Study First Submitted: 2018-01-16
• Study First Submitted QC: 2018-01-23
• Study First Posted: 2018-01-30
• Last Update Submitted: 2018-03-15
• Last Update Posted: 2018-03-16
• Primary Completion: 2018-04
• Study Completion: 2018-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Every patient undergoing general anesthesia with the use of suxamethonium for induction as assessed by the anesthesiologist

Exclusion Criteria

• Patient under 18 years old
• Pregnant woman
• Nasotracheal intubation
• Monitoring of train of four at the adductor pollis impossible (such as patient with no arm )

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time from suxamethonium injection to laryngoscopy	60 seconds after the injection of suxamethonium	Time, in seconds, between the injection of suxamethonium and the laryngoscopy realized by the anesthesiologist.
Onset of action of suxamethonium as assessed by the measurement of the train of four stimulation at the adductor pollis	60 seconds after the injection of suxamethonium	Time, in seconds, between injection of suxamethonium and appearance of a value of zero on the train of four stimulation measurement (going to for on for to zero on for).

Secondary Outcome Measures

Name	Time	Method
Number of patients whom train of four was not 0 when they benefited from the laryngoscopy	60 seconds after the injection of suxamethonium
Complications associated with use of suwamethnonium or early laryngoscopy	60 seconds after the injection of suxamethonium
Main characteristics of the patients and intubation conditions	60 seconds after the injection of suxamethonium

Trial Locations

Locations (1)

CHU Caen; 🇫🇷 Caen, France