Comparing Intubating Conditions and Patient Satisfaction Using Succinylcholine or Low-dose Rocuronium for Rigid Bronchoscopy: A Randomized Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Intubating condition
研究概览
简要总结
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), as well as patient satisfaction for these two muscle relaxants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age > 18 yr
- •scheduled for elective rigid bronchoscopy
排除标准
- •known neuromuscular disease
- •significant hepatic or renal dysfunction
- •family history of malignant hyperthermia
- •known allergy to one of the drugs used in this protocol
- •pregnancy or breastfeeding
研究组 & 干预措施
Succinylcholine
Patient received succinylcholine as a muscle relaxant(0.5 mg /kg)for induction of anaesthesia for rigid bronchoscopy.
干预措施: Succinylcholine (Drug)
Rocuronium/Sugammadex
Patient received rocuronium (0.25 mg/ kg) as muscle relaxant for induction of anaesthesia for rigid bronchoscopy, at the end of procedure rocuronium was reversed with sugammadex (0.5mg/kg.)
干预措施: Rocuronium/Sugammadex (Drug)
Rocuronium
Patients received rocuronium (0.25 mg /kg)as muscle relaxant for induction of anaesthesia for rigid bronchoscopy.
干预措施: Rocuronium (Drug)
结局指标
主要结局
Intubating condition
时间窗: After induction of general anaesthesia (after 3-5 minutes)
scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting rigid bronchoscope, vocal cord position, and coughing
次要结局
- Fasciculations(After application of the neuromuscular blocking agent (after 3-5 min))
- Postoperative Myalgia (POM)(72 Hours after Intervention)