Diclofenac (nonsteroidal anti inflammatory drug) versus pentazocine (opioid analgesic) for pain relief in acute pancreatitis

Phase 4

Recruiting

Conditions: Disorders of gallbladder, biliary tract and pancreas, patients with acute pancreatitis diagnosed as per revised Atlanta classification within 7 days of onset of illness ,

Registration Number: CTRI/2016/09/007326

Lead Sponsor: All India Institute of Medical Sciences

Brief Summary: Acute pancreatitis is an inflammatory condition of pancreas which is associated with significant abdominal pain. Relief of pain is an important component of management of patients with pancreatitis which can be achieved either by opioid analgesics or NSAIDs. Though both are effective for pain relief, NSAIDs have additional anti inflammatory property. There are only few studies either on NSAIDs or on opioids for pain relief in patients with acute pancreatitis. Also there is no definite recommendation for the most suitable analgesic for pain relief in acute pancreatitis. Hence, the present study is designed to compare diclofenac, an NSAID, with pentazocine, an opioid, for pain relief in patients with acute pancreatitis.

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: All

Target Recruitment: 50

Inclusion Criteria

patients with acute pancreatitis diagnosed as per revised Atlanta classification will be included.Patients should have abdominal pain at enrollment and should be hospitalised within 7 days of onset of acute pancreatitis.

Exclusion Criteria

Patients with organ failure (as defined by revised Atlanta classification) at enrollment 2.
Patients with altered sensorium 3.
Patients with a serum creatinine > 1.5 mg/dl 4.
Patient with a known coronary artery disease 5.
Patients admitted after 7 days of onset of acute pancreatitis 6.
Patients with paralytic ileus as defined by abdominal distention, absent bowel sounds and dilated loops on intestine 7.
Patients with evidence of chronic pancreatitis 8.
Refusal to give consent 9.
Age < 18 year or > 75 year.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
2. The need for crossover of intervention analgesic	From enrollment till 40 hours
1.Difference in efficacy of interventional analgesics for pain relief in terms of total dose and number of bad demands of rescue analgesia	From enrollment till 40 hours

Secondary Outcome Measures

Name	Time	Method
Difference in adverse events between the groups	from enrollment till 5 days

Trial Locations

Locations (1): All India Institute of Medical Sciences
🇮🇳
South, DELHI, India
All India Institute of Medical Sciences
🇮🇳South, DELHI, India
Dr Pramod Garg
Principal investigator
9868397205
pgarg10@gmail.com