Efficacy of Jessener Solution Versus Intralesional Steroid in Treatment of Alopecia Areata

Early Phase 1

• Conditions: Alopecia Areata
• Interventions: Drug: Corticosteroids Acting Locally

• Registration Number: NCT04964349
• Lead Sponsor: Al-Azhar University

Brief Summary

Alopecia areata is believed to be an autoimmune disease. Treatment primarily relies on intralesional and topical corticosteroids. This study was conducted to evaluate Jessener Solutionas a potential therapeutic modality of Alopecia Areataversusintralesional steroid as regards the efficacy, safety, tolerability, and patients' satisfaction.

Detailed Description

Background Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss.Treatment primarily relies on intralesional and topical corticosteroids.Up till now, there is nouniversally proven therapy that induces and maintains remission of Alopecia Areata in all patients.

Aims The Aim of Study is to evaluate the efficacyof Jessener solution versus intralesional steroid in treatment of Alopecia Areata.

Patients and Methods The study will include 40 patients diagnosed clinically and dermoscopically as Alopecia Areata with more than two patches of alopecia areata were included. Two treatment modalities with intralesional corticosteroid and topical Jessener Solutionas were performed in two randomly selected patches. Three sessions were done, 3 weeks apart and were followed-up for three months. Evaluation was done using Mac Donald Hull and Norris grading system , Serial photographs and dermoscopic , trichoscopic examination every month will be done and patient will be score.

Study Timeline

• Study Start: 2021-04-21
• Status Verified: 2021-07
• Study First Submitted: 2021-07-13
• Study First Submitted QC: 2021-07-13
• Last Update Submitted: 2021-07-13
• Study First Posted: 2021-07-16
• Last Update Posted: 2021-07-16
• Primary Completion: 2021-10-21
• Study Completion: 2021-11-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1.Alopecia Areatamultilocuolaris.2.Age from18-50years old. 3.Wash out period is two months. 4.Ophiasis pattern alopecia areata.

Exclusion Criteria

• Age less than 12 yearsand more than 40years old. 2.Patient under treatment.3.Patients having another dermatological condition affecting thescalpas eczema.4.Patients with psychiatric disorders.5.Pregnant and lactating females.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intralesional cortisosteroid injection	Corticosteroids Acting Locally	Intralesional corticosteroid injection
jessener solution	Corticosteroids Acting Locally	topical jessener solution

Primary Outcome Measures

Name	Time	Method
Effecacy of topical jessener solution in treatment of alopecia areata	6 monthes	Effecacy of topical jessener solution in treatment of alopecia areata

Trial Locations

Locations (1)

Alazhar faculty of meidicine; 🇪🇬 Cairo, Egypt