MMP-9 Monitoring Particulate Cerebral Embolisation

Completed

• Conditions: Cerebral Embolic Damage
• Interventions: Procedure: vein blood collection

• Registration Number: NCT02109120
• Lead Sponsor: Peking Union Medical College Hospital

Brief Summary

1. In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified.

2. And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-02
• Status Verified: 2013-09
• Primary Completion: 2013-10
• Study Completion: 2013-11
• Study First Submitted: 2014-04-07
• Study First Submitted QC: 2014-04-08
• Last Update Submitted: 2014-04-08
• Study First Posted: 2014-04-09
• Last Update Posted: 2014-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

-All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a <70% stenosis but obvious cerebral ischema symptoms had been existed.

Exclusion Criteria

• Exclusion criteria included poor temporal window
• Refused to cooperate with us
• Nonatheromatous such as takayasu arteritis and fibromuscular dysplasia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
carotid endarterectomy (CEA)	vein blood collection	CEA patients with vein blood collection

Primary Outcome Measures

Name	Time	Method
postoperative ischemic stroke	7 days after surgery

Secondary Outcome Measures

Name	Time	Method
postoperative elevation of plasma MMP9	perioperative phage

Trial Locations

Locations (1)

vascular surgery department of PUMCH; 🇨🇳 Beijing, Beijing, China