Changes in middle cerebral artery blood flow velocity during the early phase of fluid resuscitation in septic intensive care patients
Completed
- Conditions
- blood-poisoning or septicemiasepsis10004018
- Registration Number
- NL-OMON38500
- Lead Sponsor
- Martini Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
ICU patient in Martini hospital Groningen
Diagnosed sepsis; either severe sepsis or septic shock
Noradrenaline dependency at ICU admission
Pulmonary artery catheter in situ
Exclusion Criteria
Younger than 18 years
Absence of relatives who can give informed consent on behalf of the temporarily incapacitated subject
Insufficient temporal window for TCD investigation
Life expectance of less than 2 days at ICU admission
Intracranial infection
Pre-existing brain injury
Pre-existing cardiac insufficiency
Immune compromised
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the change in blood flow velocity in the MCA<br /><br>measured by TCD as a result of initial fluid resuscitation. The study is ended<br /><br>when 16 subjects, in whom written consent has been obtained, have successfully<br /><br>completed the entire study.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameter is the fluid responsiveness. This is determined<br /><br>by the gold standard for cardiac output determination, namely a thermodilution<br /><br>measurement by means of an in situ pulmonary artery catheter. Other study<br /><br>parameters which might intervene with the main study parameter are the blood<br /><br>pressure, heart frequency and CO2 level. </p><br>