Preventing mood and anxiety disorders in youth: a multicentre prevention trial in the high risk offspring of depressed and anxious patients - Offspring of parents with mood and anxiety disorders

Rijksuniversiteit Groningen0 个研究点目标入组 204 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•Inclusion criteria (parents): at least one of the biological parents is currently being treated for a depression (MDD, dysthymia) or an anxiety disorder (Social phobia SocP, Agoraphobia AP, Panic disorder PD, Generalized anxiety disorder GAD, Separation anxiety disorder SAD); informed consent.
•Inclusion criteria (offspring): age 8-18; being at risk for developing a depression or anxiety disorder, defined as meeting at least 2 of the 3 criteria of the High Risk Index (risk factors: female sex, 2 affected parents, suicide attempt of one of the parents; see Ch. 1) or reporting subthreshold symptoms of anxiety or depression, defined as scoring above the 80th percentile of the RCADS questionnaire (we chose a relatively high cutoff value for the RCADS, to enhance specificity); informed consent.

•Exclusion criteria (both parents): mental retardation; index parent is not fluent in Dutch; severe alcohol or substance use disorder; schizophrenia or other primary psychotic disorder; schizoaffective disorder; bipolar disorder BPD, Obsessive-compulsive disorder OCD, PTSD, only simple phobia SP.
•Exclusion criteria (offspring): mental retardation; not speaking Dutch fluently; severe alcohol or substance use disorder; current diagnosis of MDD, dysthymia, SocP, AP, PD, GAD, BPD, PTSD, OCD, SP; previous or current treatment for a DSM-IV psychiatric disorder.

发起方

Rijksuniversiteit Groningen