Evaluation of Sticky Bone With or Without EDTA for Treatment of Gingival Recession

Not Applicable

Recruiting

• Conditions: Gingival Recession
• Interventions: Procedure: Sticky bone; Procedure: Sticky bone and EDTA

• Registration Number: NCT04980066
• Lead Sponsor: Kafrelsheikh University

Brief Summary

Gingival recession is a common clinical finding in periodontal disease which is frequently associated with esthetic concerns, root hypersensitivity, and root caries. Many surgical therapeutic approaches have been developed to predictably obtain root coverage of gingival recession defects. Injectable PRF (I-PRF) is the liquid form of PRF. I-PRF is a bioactive agent obtained by low-speed centrifugation, and it has the capacity to stimulate tissue regeneration. At high concentrations, PRF may stimulate the secretion of several growth factors and trigger fibroblast migration. I-PRF is generally used in regenerative treatments, with good outcomes. Ethylenediaminetetraaceti acid (EDTA) is a chelating agent that could enhance the attachment of connective tissue to the root surface by exposing collagen and, as a consequence, enhance root coverage. EDTA works at neutral pH, and this property has been reported to preserve adjacent tissue vitality. The present study will be carried out to evaluate the effect of sticky bone with or without EDTA root surface biomodification for treatment of gingival recession.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-06-24
• Study First Submitted QC: 2021-07-17
• Study First Posted: 2021-07-28
• Study Start: 2021-08-03
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-11
• Primary Completion: 2024-08
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Miller I/II isolated maxillary recession defects.
• No abrasion, caries, or cervical restorations and presence of identifiable cementoenamel junction (CEJ).
• No occlusal interferences.
• Full-mouth plaque index (PI) and gingival index (GI) scores of < 1.
• Non-smokers.

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Exclusion Criteria

• Pregnant patients
• Presence of systemic disease or taking medication that interfere with periodontium

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sticky bone	Sticky bone	treatment of gingival recession using sticky bone
sticky bone and EDTA	Sticky bone and EDTA	treatment of gingival recession using sticky bone after root surface biomodification with EDTA

Primary Outcome Measures

Name	Time	Method
clinical evaluation of root coverage	6 months	the percentage of root coverage will be calculated in millimeter

Trial Locations

Locations (1)

Faculty of Dentistry, Kafrelsheikh University; 🇪🇬 Kafr El-sheikh, Egypt