Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cleft Lip and Palate
- Sponsor
- University of Alexandria
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Measurement of periodontal inflammatory mediators
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
Detailed Description
Segmental forward maxillary distraction osteogenesis(DO)was performed. Distractor connecting buccal molar segments to the anterior maxilla was kept for 7 days. Then distraction was performed till overcorrection and consolidated for 3-months. Periodontal clinical parameters were recorded at baseline, 3 and 6-months postoperatively. Gingival crevicular fluid was collected . Soft tissue healing was evaluated clinically and histologically after distraction.
Investigators
Marwa Ibrahim Madi
Principle investigator
University of Alexandria
Eligibility Criteria
Inclusion Criteria
- •Severe maxillary hypoplasia and negative anterior overjet
Exclusion Criteria
- •Systemic disease
Outcomes
Primary Outcomes
Measurement of periodontal inflammatory mediators
Time Frame: 7 days
periodontal inflammatory mediators IL-1β
Secondary Outcomes
- Assessment of clinical attachment loss(3 and 6 month)
- Measurement of periodontal inflammatory mediators TNF- α(7 days)
- Assessment of periodontal probing depth(3 and 6 month)
- Assessment of periodontal clinical parameters(3 and 6 month)