Impact of Human Papillomavirus Carriage on IVF/ICSI Results (HPV AMP)

Recruiting

• Conditions: Infertility, Female; Human Papilloma Virus

• Registration Number: NCT06550531
• Lead Sponsor: University Hospital, Brest

Brief Summary

The prevalence of the papilloma virus in the general population is 12%. This virus is known to impair male fertility but its impact on female infertility remains uncertain. This is a public health problem since there is a vaccination protocol. Demonstrating the impact of the human papillomavirus on fertility would be an argument in favor of vaccination.

Detailed Description

This is a single-center prospective study in the assisted reproduction center of Brest University Hospital. All new patients coming to consult will be offered participation in the study. The HPV test will be updated if it is older than 12 months. We will analyze stimulation results and pregnancy outcomes according to HPV status. Inclusions will take place over 3 years

Study Timeline

• Study Start: 2022-02-04
• Study First Submitted: 2022-03-31
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-09
• Last Update Submitted: 2024-08-09
• Study First Posted: 2024-08-13
• Last Update Posted: 2024-08-13
• Primary Completion: 2026-02-04
• Study Completion: 2026-02-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 618

Inclusion Criteria

• all etiology of infertility AMH > ou = à 1.1 ng/ml First ou second protocol of IVF between 25 years and 37 years and 11 months

Exclusion Criteria

Age < 25 y Age > ou = 38 y AMH < 1.1 ng/ml patient under juridic protection rejection of participation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
clinical pregnancy rate after fresh eSET by HPV status	1 year	A clinical pregancy is the visualisation of a gestational sac inside the uterus after 6 weeks of gestation

Secondary Outcome Measures

Name	Time	Method
Positive HPV rate	1 year	number of women who have a positive HPV test before IVF procedure
IVF issues	1 year	oocytes number, embryos number, fecondation rate, implantation rate

Trial Locations

Locations (1)

CHRU de Brest; 🇫🇷 Brest, France