ongterm effects of cannabis and amphetamin use and social-emotional brainfunctions

Conditions: F15.2
F12.2

Registration Number: DRKS00004526

Lead Sponsor: Ministerium für Innovation, Wissenschaft, Forschung und Technologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 150

Inclusion Criteria

Cannabinoid-dependence, Amphetamin-dependence according to the criteria of the ICD-10: control group: persons without any mental disorder and no consumption of any illicit drugs more than five times in life

Exclusion Criteria

Epilepsy, apoplexia, multiple sclerosis, myasthenia gravia, coronary heart disease, Diabetes Mellitus, chronic obstructive pulmonary diseases, psychiatric medication, long-term medication (exception: contraceptives), consumption of legal or illegal psychotropic drugs during the last 28 days (exception: nicotine, alcohol), alcohol consumption for the day of the procedure, heart/head operation, hearing aids, cardiac pacemaker, drug pumps, removable dental protheses, metal parts in or around the body (e. g. metal shivers, artificial hip-joints, acupuncture devices, implanted, electrodes, unremovable piercings, metal-containing tattoos), claustrophobia, pregnancy, lactation, unsecure contraception, axis I or II mental disorder (DSM-IV) except cannabis or amphetamin dependence. consumption of acohol more than twice a month excessively or frequent heavy drinkung during the past six month.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Procentual personal signal change of the fMRI-signal in the task related target areas. measurement during the processing of the socia-emotional tasks and before and after taking part in the virtual ball game (Cyberball).

Secondary Outcome Measures

Name	Time	Method
General parameters of social-cognitive functions, measured by the emotional recognition task. Effects of taking part in the cyberball game in the manipulation check using the need-threat-scale. Group differences on the rejection sensitivity scale with pre-post-comparison.