Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Not Applicable
Completed
- Conditions
- Acute Kidney Injury
- Registration Number
- NCT02423642
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Systemic inflammatory response syndrome; SIRS > or = 2 meets definition
- Patients with acute kidney injury in the intensive care ward.
- Requiring continuous renal replacement therapy.
Exclusion Criteria
- Pregnancy
- Cirrhosis
- End stage renal disease
- HIV infection
- Serum creatinine in male > 2 mg/dl and female > 1.5 mg/dl
- Bleeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Regulation of inflammatory reactions and and opsonization in microorganisms 24 hours C3a and C5a
Activity of acute phase protein during acute inflammation 24 hours PAI-1
Functions of inflammatory cells 24 hours CD11b expression on PMN and HLA-DR expression on monocyte
- Secondary Outcome Measures
Name Time Method length of ICU stay 28 days survival rate 28 days
Trial Locations
- Locations (1)
Sasipha Tachaboon
🇹🇭Bangkok, Pathumwan, Thailand
Sasipha Tachaboon🇹🇭Bangkok, Pathumwan, Thailand