NCT02423642已完成不适用
Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Regulation of inflammatory reactions and and opsonization in microorganisms
研究概览
简要总结
The purpose of this study is to study the effect of anticoagulation in immune response with Acute Kidney Injury (AKI) undergoing Continuous Renal Replacement Therapy (CRRT).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Systemic inflammatory response syndrome; SIRS > or = 2 meets definition
- •Patients with acute kidney injury in the intensive care ward.
- •Requiring continuous renal replacement therapy.
排除标准
- •Pregnancy
- •Cirrhosis
- •End stage renal disease
- •HIV infection
- •Serum creatinine in male > 2 mg/dl and female > 1.5 mg/dl
结局指标
主要结局
Regulation of inflammatory reactions and and opsonization in microorganisms
时间窗: 24 hours
C3a and C5a
Activity of acute phase protein during acute inflammation
时间窗: 24 hours
PAI-1
Functions of inflammatory cells
时间窗: 24 hours
CD11b expression on PMN and HLA-DR expression on monocyte
次要结局
- length of ICU stay(28 days)
- survival rate(28 days)
研究者
Nattachai Srisawat ,M.D.
Division of Nephrology, Department of Medicine, Faculty of Medicine
Chulalongkorn University
研究点 (2)
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